Sensitivity, specificity, cumulative specificity, positive predictive value, negative predictive value, model accuracy and area under the receiver operating characteristic curve with 95% CI for DIGIROP-Birth and DIGIROP-Screen (Swedish Contemporary Validation Cohort 2018–2020)
| Sensitivity | Specificity | Cumulative specificity | Positive predictive value | Negative predictive value | Model accuracy | Area under the ROC curve | ||
| Model and time point | n/N* | % (95% CI) | % (95% CI) | % (95% CI) | % (95% CI) | % (95% CI) | % (95% CI) | AUC (95% CI) |
| DIGIROP-Birth | 55/57†‡ | 96.5 (87.9 to 99.6) | 49.9 (46.7 to 53.0) | 49.9 (46.7 to 53.0) | 9.7 (7.4 to 12.4) | 99.6 (98.6 to 100.0) | 52.3 (49.3 to 55.3) | 0.93 (0.90 to 0.95) |
| DIGIROP-Screen PNA6w | 55/57†‡ | 96.5 (87.9 to 99.6) | 48.9 (45.8 to 52.0) | 50.0 (46.8 to 53.1) | 9.5 (7.2 to 12.2) | 99.6 (98.6 to 100.0) | 51.4 (48.4 to 54.4) | 0.93 (0.90 to 0.95) |
| DIGIROP-Screen PNA7w | 55/57†‡ | 96.5 (87.9 to 99.6) | 48.1 (45.0 to 51.2) | 50.9 (47.8 to 54.0) | 9.4 (7.1 to 12.0) | 99.6 (98.5 to 100.0) | 50.6 (47.6 to 53.7) | 0.93 (0.90 to 0.96) |
| DIGIROP-Screen PNA8w | 54/56†‡ | 96.4 (87.7 to 99.6) | 54.3 (51.2 to 57.4) | 57.4 (54.3 to 60.4) | 10.3 (7.9 to 13.3) | 99.6 (98.7 to 100.0) | 56.5 (53.5 to 59.5) | 0.93 (0.90 to 0.96) |
| DIGIROP-Screen PNA9w | 52/54†‡ | 96.3 (87.3 to 99.5) | 62.8 (59.8 to 65.8) | 66.0 (63.0 to 68.9) | 12.0 (9.1 to 15.4) | 99.7 (98.9 to 100.0) | 64.5 (61.6 to 67.4) | 0.94 (0.91 to 0.96) |
| DIGIROP-Screen PNA10w | 51/52† | 98.1 (89.7 to 100.0) | 67.0 (64.1 to 69.9) | 70.2 (67.3 to 73.0) | 13.1 (9.9 to 16.9) | 99.9 (99.2 to 100.0) | 68.5 (65.7 to 71.3) | 0.94 (0.91 to 0.96) |
| DIGIROP-Screen PNA11w | 40/43द | 93.0 (80.9 to 98.5) | 70.0 (67.1 to 72.8) | 72.8 (69.9 to 75.5) | 11.5 (8.4 to 15.4) | 99.6 (98.8 to 99.9) | 71.0 (68.1 to 73.7) | 0.94 (0.91 to 0.96) |
| DIGIROP-Screen PNA12w | 29/31ठ| 93.5 (78.6 to 99.2) | 70.0 (67.1 to 72.8) | 72.8 (69.9 to 75.5) | 8.6 (5.9 to 12.2) | 99.7 (99.0 to 100.0) | 70.7 (67.9 to 73.5) | 0.94 (0.91 to 0.96) |
| DIGIROP-Screen PNA13w | 24/25‡ | 96.0 (79.6 to 99.9) | 77.0 (74.3 to 79.5) | 78.7 (76.1 to 81.2) | 9.2 (6.0 to 13.4) | 99.9 (99.3 to 100.0) | 77.4 (74.8 to 79.9) | 0.94 (0.92 to 0.96) |
| DIGIROP-Screen PNA14w | 10/10 | 100.0 (69.2 to 100.0) | 76.3 (73.6 to 78.9) | 78.7 (76.1 to 81.2) | 4.0 (1.9 to 7.1) | 100.0 (99.5 to 100.0) | 76.5 (73.8 to 79.1) | 0.97 (0.95 to 0.99) |
*Infants are followed up until their first ROP treatment, why the number of patients at risk among those requiring treatment in the future (N) decreases along the screening.
†Severe medical condition (intraventricular haemorrhage, hydrocephalus), ROP treatment stage 3, zone II–III, pre-plus disease.
‡Syndrome (Beckwith-Wiedemann), ROP treatment zone II–III, plus disease right eye, pre-plus disease left eye.
§Severe medical condition (necrotising enterocolitis, small for gestational age, bronchopulmonary dysplasia), incomplete examinations (hazy eyes), ROP treatment stage 3, zone II–III, pre-plus disease.
¶Severe medical condition (small for gestational age, iatrogen chylothorax), incomplete (hazy eyes) and missed examinations, ROP treatment stage 3 zone II, plus disease.
AUC, area under the curve; PNA, postnatal age; ROC, receiver operating characteristic; w, weeks.