Characteristic | Sham pooled (N=65) | PEOM (N=61) | P value versus sham | PM (N=71) | P value versus sham | All (N=197) |
Gender | ||||||
Female | 39 (60.0%) | 40 (65.6%) | 45 (63.4%) | 124 (62.9%) | ||
Male | 26 (40.0%) | 21 (34.4%) | 26 (36.6%) | 73 (37.1%) | ||
Age (years) | ||||||
Mean (SD) | 77.9 (7.58) | 80.3 (7.43) | 80.4 (7.44) | 79.5 (7.53) | ||
Median (Min, Max) | 78.0 (60.0, 96.0) | 80.0 (60.0, 97.0) | 81.0 (63.0, 95.0) | 80.0 (60.0, 97.0) | ||
Baseline VA (ETDRS letters) | ||||||
Mean (SD) | 52.4 (22.5) | 56.3 (20.1) | 55.5 (19.0) | 54.7 (20.5) | ||
Median (Min, Max) | 58.0 (0, 85.0) | 60.0 (4.00, 89.0) | 58.0 (0, 83.0) | 59.0 (0, 89.0) | ||
RORA (mm2) | ||||||
Mean (SD) | 7.10 (3.63) | 7.36 (3.62) | 0.660 | 6.59 (2.94) | 0.578 | 7.00 (3.39) |
Median (Min, Max) | 6.33 (2.02, 16.6) | 7.74 (2.08, 15.5) | 6.05 (1.59, 13.8) | 6.33 (1.59, 16.6) | ||
PRD (mm2) | ||||||
Mean (SD) | 12.8 (5.51) | 13.6 (5.89) | 0.557 | 12.5 (4.64) | 0.794 | 13.0 (5.33) |
Median (Min, Max) | 12.3 (3.35, 26.4) | 13.8 (3.53, 26.4) | 12.0 (4.54, 24.3) | 12.6 (3.35, 26.4) | ||
PRD in isolation (mm2) | ||||||
Mean (SD) | 5.12 (2.87) | 5.76 (3.71) | 0.680 | 5.53 (2.96) | 0.680 | 5.47 (3.18) |
Median (Min, Max) | 4.59 (0.690, 14.7) | 4.77 (1.08, 17.8) | 4.50 (1.25, 14.3) | 4.61 (0.690, 17.8) | ||
RPE loss (mm2) | ||||||
Mean (SD) | 7.71 (4.03) | 7.91 (3.82) | 0.756 | 7.06 (3.04) | 0.440 | 7.54 (3.64) |
Median (Min, Max) | 7.09 (2.43, 21.4) | 7.79 (2.24, 15.9) | 6.54 (1.99, 14.3) | 6.92 (1.99, 21.4) | ||
Hypertransmission (mm2) | ||||||
Mean (SD) | 8.18 (3.92) | 8.67 (3.93) | 0.601 | 7.84 (3.34) | 0.601 | 8.21 (3.72) |
Median (Min, Max) | 7.60 (2.60, 19.3) | 8.73 (2.57, 17.2) | 7.39 (1.73, 15.7) | 7.80 (1.73, 19.3) | ||
Intact macula (mm2) | ||||||
Mean (SD) | 13.7 (5.92) | 13.5 (5.97) | 0.777 | 14.5 (4.99) | 0.649 | 13.9 (5.61) |
Median (Min, Max) | 13.9 (0.202, 24.0) | 13.2 (0.360, 24.1) | 14.1 (1.67, 23.6) | 13.9 (0.202, 24.1) | ||
Perimeter (mm) | ||||||
Mean (SD) | 23.9 (10.3) | 24.7 (11.2) | 0.955 | 23.8 (11.7) | 0.955 | 24.1 (11.1) |
Median (Min, Max) | 21.9 (7.19, 60.9) | 24.4 (7.56, 58.4) | 19.6 (7.21, 55.3) | 21.9 (7.19, 60.9) | ||
Focality | ||||||
Mean (SD) | 2.94 (2.08) | 3.43 (2.48) | 0.571 | 3.07 (2.38) | 0.741 | 3.14 (2.32) |
Median (Min, Max) | 2.00 (1.00, 10.0) | 3.00 (1.00, 10.0) | 2.00 (1.00, 12.0) | 2.00 (1.00, 12.0) |
ETDRS, Early Treatment of Diabetic Retinopathy Study; PEOM, pegcetacoplan every other month; PM, pegcetacoplan monthly; PRD, photoreceptor degeneration; RORA, RPE and outer retinal atrophy; RPE, retinal pigment epithelium; VA, Visual Acuity.