Table 2

Performance of retinopathy detection and subtype diagnosis using preoperative and generated CFP and UWF images in the test dataset

Preoperative imagesGenerated imagesP1P2P3P4
SensitivitySpecificityAccuracyAUCSensitivitySpecificityAccuracyAUC
CFPRetinopathy detection0.721 (0.604, 0.813)0.906 (0.758, 0.968)0.78 (0.689, 0.850)0.905 (0.848, 0.963)0.941 (0.858, 0.977)0.844 (0.683, 0.931)0.91 (0.838, 0.952)0.971 (0.938, 1)0.0010.7050.0190.032
AMD0.25 (0.089, 0.532)0.977 (0.921, 0.994)0.89 (0.814, 0.938)0.828 (0.754, 0.902)0.833 (0.552, 0.953)0.989 (0.938, 0.999)0.97 (0.916, 0.99)0.976 (0.946, 1)0.01410.0520.091
DR0.636 (0.354, 0.848)0.978 (0.922, 0.994)0.94 (0.875, 0.972)0.989 (0.969, 1)1 (0.741, 1)1 (0.959, 1)1 (0.963, 1)1 (1, 1)0.0970.4770.0380.272
PM0.759 (0.579, 0.878)0.93 (0.846, 0.97)0.88 (0.802, 0.93)0.97 (0.937, 1)0.966 (0.828, 0.998)1 (0.949, 1)0.99 (0.946, 1)0.997 (0.986, 1)0.0570.0690.0040.060
Others0.438 (0.231, 0.668)0.952 (0.884, 0.981)0.87 (0.79, 0.922)0.945 (0.9, 0.99)0.813 (0.57, 0.934)0.988 (0.936, 0.999)0.96 (0.902, 0.984)0.989 (0.969, 1)0.0680.3640.0430.079
UWFRetinopathy detection0.972 (0.903, 0.992)0.759 (0.579, 0.878)0.91 (0.838, 0.952)0.968 (0.944, 1)0.958 (0.883, 0.986)0.862 (0.694, 0.945)0.93 (0.863, 0.966)0.983 (0.958, 1)10.5030.7940.434
Glaucoma0.636 (0.354, 0.848)0.989 (0.939, 0.999)0.95 (0.888, 0.979)0.988 (0.967, 1)0.818 (0.523, 0.949)0.989 (0.939, 0.999)0.97 (0.916, 0.99)0.996 (0.984, 1)0.63210.7180.408
Lattice/hole0.615 (0.355, 0.823)0.954 (0.888, 0.982)0.91 (0.838, 0.952)0.975 (0.944, 1)0.846 (0.578, 0.957)0.977 (0.92, 0.994)0.96 (0.902, 0.984)0.993 (0.977, 1)0.3770.6780.2510.239
RD0.455 (0.213, 0.72)0.921 (0.846, 0.961)0.87 (0.79, 0.922)0.957 (0.917, 0.997)0.818 (0.523, 0.949)0.989 (0.939, 0.999)0.97 (0.916, 0.99)0.997 (0.986, 1)0.1840.070.0190.085
Others0.806 (0.65, 0.903)0.984 (0.917, 0.999)0.92 (0.85, 0.959)0.967 (0.932, 1)0.917 (0.782, 0.971)1 (0.943, 1)0.97 (0.916, 0.99)0.995 (0.981, 1)0.30710.2150.346
  • P1 indicates the p value calculated between the sensitivities of preoperative images and generated images using McNemar’s test. P2 indicates the p value calculated between the specificities of preoperative images and generated images using McNemar’s test. P3 indicates the p value calculated between the accuracies of preoperative images and generated images using McNemar’s test. P4 indicates the p value calculated between the AUCs of preoperative images and generated images using DeLong’s test.

  • AMD, age-related macular degeneration; AUC, area under the curve; CFP, colour fundus photography; DR, diabetic retinopathy; PM, pathological myopia; RD, retinal detachment; UWF, ultra-wide field.