Table 1

Incremental cost-effectiveness measures (model-based analysis)

Time horizon	Intervention	Cost (£)	Δ Cost (£)	QALY	ΔQALY	ICER (Δ Cost/ΔQALY) (£)	NMB	Probability cost-effective at Rc
Time horizon	Intervention	Cost (£)	Δ Cost (£)	QALY	ΔQALY	ICER (Δ Cost/ΔQALY) (£)	NMB	0	£10 000	£20 000	£50 000
EQ-5D-based QALYs
2-year time horizon	Trabeculectomy	3436	2106	1.23	0.04	47 663	21 108	0.1	0.26	0.39	0.5
2-year time horizon	Medication	1330	2106	1.18	0.04	47 663	22 330	0.9	0.74	0.61	0.5
10-year time horizon	Trabeculectomy	5421	2362	3.72	0.17	13 911	69 024	0.08	0.4	0.59	0.73
10-year time horizon	Medication	3059	2362	3.55	0.17	13 911	67 990	0.92	0.6	0.41	0.27
Lifetime horizon	Trabeculectomy	7273	2687	5.92	0.28	9679	111 052	0.08	0.5	0.73	0.85
Lifetime horizon	Medication	4586	2687	5.64	0.28	9679	108 187	0.92	0.5	0.27	0.15
HUI-based QALYs
2-year time horizon	Trabeculectomy	3436	2106	1.17	0.05	39 724	19 978	0.09	0.29	0.4	0.52
2-year time horizon	Medication	1330	2106	1.12	0.05	39 724	21 024	0.91	0.71	0.6	0.48
10-year time horizon	Trabeculectomy	5421	2362	3.58	0.22	10 506	66 115	0.1	0.5	0.65	0.75
10-year time horizon	Medication	3059	2362	3.35	0.22	10 506	63 980	0.9	0.5	0.35	0.25
Lifetime horizon	Trabeculectomy	7273	2687	5.70	0.38	7016	106 779	0.06	0.62	0.81	0.88
Lifetime horizon	Medication	4586	2687	5.32	0.38	7016	101 806	0.94	0.38	0.19	0.12
GUI-based QALYs
2-year time horizon	Trabeculectomy	3436	2106	1.24	0.01	147 247	21 302	0.09	0.18	0.28	0.41
2-year time horizon	Medication	1330	2106	1.23	0.01	147 247	23 122	0.91	0.82	0.72	0.59
10-year time horizon	Trabeculectomy	5421	2362	3.73	0.1	24 179	69 269	0.08	0.26	0.44	0.6
10-year time horizon	Medication	3059	2362	3.64	0.1	24 179	69 677	0.92	0.74	0.56	0.4
Lifetime horizon	Trabeculectomy	7273	2687	5.92	0.16	16 805	111 165	0.06	0.32	0.55	0.74
Lifetime horizon	Medication	4586	2687	5.76	0.16	16 805	110 655	0.94	0.68	0.45	0.26

EQ-5D, EuroQol Five Dimension; GUI, glaucoma utility index; HUI, health utilities index; ICER, incremental cost-effectiveness ratio; NMB, net monetary benefit; QALY, quality-adjusted life-year; Rc, ceiling ratio of willingness to pay per QALY gained.