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Identification of a Fission Yeast Dynamin-Related Protein Involved in Mitochondrial DNA Maintenance

https://doi.org/10.1006/bbrc.1998.9539Get rights and content

Abstract

Members of the dynamin-related proteins family have been identified in a wide range of organisms, however their precise functions remain elusive. We have identified a new member of that GTPase family in the fission yeastSchizosaccharomyces pombe.We show thatMsp1+is an essential nuclear gene encoding a 101 kDa protein whose closest homologue is theS. cerevisiaeMGM1 gene product. We also report that msp1 conditional loss of function affects the maintenance of mitochondrial DNA and leads to growth arrest associated with respiratory deficiency.

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