Biochemical and Biophysical Research Communications
Regular ArticleIdentification of a Fission Yeast Dynamin-Related Protein Involved in Mitochondrial DNA Maintenance
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2021, Progress in Retinal and Eye ResearchCitation Excerpt :Associating the OPA1 gene with DOA established the first link between a mitochondrial disease and a process not directly related to the respiratory chain. Indeed, OPA1 orthologues in the budding (MGM1) (Guan et al., 1993) and fission (msp1) (Pelloquin et al., 1998) yeasts are involved in mitochondrial membrane fusion and genome maintenance (Alexander et al., 2000; Delettre et al., 2000; Lenaers et al., 2002). This goes along with the presence in OPA1, MGM1 and Msp1 of conserved protein sequences related to a dynamin signature, including a GTPase domain, followed by a middle stalk domain and a coiled-coil GTPase effector domain (GED).
Mitochondrial Fusion: The Machineries In and Out
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2016, Neurobiology of DiseaseCitation Excerpt :MFN2 was found to interact with Miro-proteins and its mutation was shown to hamper mitochondrial transport in axons (Chapman et al., 2013; Misko et al., 2012). We identified OPA1 “in silico” as a human homolog of the fusogenic yeast proteins Mgm1p and Msp1p (Delettre et al., 2000; Guan et al., 1993; Pelloquin et al., 1998). Human OPA1 ORF comprises 30 exons, 3 of which are alternatively spliced leading to 8 mRNA (Fig. 2C) (Delettre et al., 2001).
Mechanistic perspective of mitochondrial fusion: Tubulation vs. fragmentation
2013, Biochimica et Biophysica Acta - Molecular Cell ResearchThe dynamin GTPase OPA1: More than mitochondria?
2013, Biochimica et Biophysica Acta - Molecular Cell Research
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