Regular ArticleRegulation of Fibronectin and Laminin Synthesis by Retinal Capillary Endothelial Cells and Pericytes In Vitro
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2022, iScienceCitation Excerpt :Fibronectin is expressed during development, especially in vascular morphogenesis, and vascular injury.42,43,44 Pericytes are expressed ten times more fibronectin than ECs.45 Furthermore, RNA-seq analysis results revealed that the fibronectin mRNA level was upregulated in pericytes and downregulated in Ccm1 conditional knockout ECs (Table 1).
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2021, Progress in Retinal and Eye ResearchCitation Excerpt :However, under HG condition, endothelial cells were reported to show a three-fold increase in fibronectin expression while pericytes showed a generalized but insignificant fibronectin upregulation (Mandarino et al., 1993). Interestingly, an experiment using [35S] methionine radiolabelling immunoprecipitation also demonstrated that endothelial cells and pericytes synthesize different forms of fibronectin, with endothelial cells producing a dimer of two subunits each weighing 220 kD whereas pericytes producing fibronectin consisting of multiple subunits, with one predominant form at 225 kD (Mandarino et al., 1993). Both pericytes and endothelial cells synthesize an α- and two β-chains of laminin of similar size but were reported to have differential post-translational modification in each cell type.