Regular articleThe Significance of Ascorbate in the Aqueous Humour Protection Against UV-A and UV-B
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Hallmarks of lens aging and cataractogenesis
2021, Experimental Eye ResearchRegional differences in glutathione accumulation pathways in the rat cornea: Mapping of amino acid transporters involved in glutathione synthesis
2017, Experimental Eye ResearchCitation Excerpt :In addition, two important non-enzymatic antioxidants exist in the cornea; ascorbic acid and reduced glutathione (GSH). Ascorbic acid (Vitamin C) is found in high concentrations in the corneal epithelium (Brubaker et al., 2000), where it acts to absorb UV radiation (Ringvold, 1996). While ascorbic acid is found at higher levels in the epithelium compared to GSH (Brubaker et al., 2000; Riley and Yates, 1977), GSH is essential for reducing oxidised ascorbic acid to ascorbic acid to maintain ascorbic acid levels (Wu et al., 1998).
Vitamin C Functions in the Cornea: Ultrastructural Features in Ascorbate Deficiency
2014, Handbook of Nutrition, Diet and the EyeSelenium and pseudoexfoliation syndrome
2011, American Journal of OphthalmologyCitation Excerpt :It is for this purpose that aqueous humor contains a series of molecules such as ascorbic acid, urate, L-tyrosine, L-cysteine, and glutathione (GSH) that protect the eye against free radical damage. Ascorbic acid is the most important of these molecules in terms of ocular antioxidant defense.19–21 A nonenzymatic extracellular oxido-reduction system has been postulated as a major mechanism for protecting the anterior eye from free radical damage and H2O2 toxicity.22
Antioxidant defenses in the ocular surface
2009, Ocular Surface
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