Letter to the Editor

doi:10.1006/exer.1996.0068

Experimental Eye Research

Volume 62, Issue 5, May 1996, Pages 581-584

https://doi.org/10.1006/exer.1996.0068 Get rights and content

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Cited by (6)

Acute anterior uveitis and HLA-B27
2005, Survey of Ophthalmology
Citation Excerpt :
The animal models of anterior uveitis discussed above have allowed better elucidation of the immunopathogenic cellular mechanisms in anterior uveitis including the roles of various cytokines, chemokines, and adhesion molecules in the multi-step process of leukocyte recruitment to the eye. Various cytokines, including pro-inflammatory cytokines such as TNF-α, IL-1, and IFN-γ, as well as immunoregulatory cytokines such as IL-10 and TGF-β, have been implicated to play a major role in the pathogenesis of AAU in experimental models.48,49,74,155 Some of these findings have also been confirmed in human studies of uveitis.
Acute anterior uveitis is the most common form of uveitis. HLA-B27-associated acute anterior uveitis is a distinct clinical entity that has wide-ranging medical significance due to its ocular, systemic, immunologic, and genetic features. The association between HLA-B27 and the spectrum of HLA-B27-associated inflammatory diseases remains one of the strongest HLA-disease associations known to date. This review examines acute anterior uveitis with particular focus on HLA-B27-associated acute anterior uveitis, including the epidemiology, immunopathology, association with HLA-B27 and its subtypes, clinical features, complications, prognosis, and potential new therapies such as anti-TNFα therapy and oral HLA-B27-peptide tolerance. There have been substantial recent advances in both clinical and basic scientific research in this field, including studies of the various animal models of acute anterior uveitis and the HLA-B27 transgenic animals, and these are summarized in this review. To the ophthalmologist, HLA-B27-associated acute anterior uveitis is an important clinical entity that is common, afflicts relatively young patients in their most productive years, and is associated with significant ocular morbidity due to its typically recurrent attacks of inflammation and its potentially vision-threatening ocular complications. Furthermore, to the ophthalmologist and the internist, HLA-B27-associated acute anterior uveitis is also of systemic importance due to its significant association with extraocular inflammatory diseases.
Endotoxin-induced uveitis causes long-term changes in trigeminal subnucleus caudalis neurons
2005, Journal of Neurophysiology
Biphasic ocular inflammatory response to endotoxin-induced uveitis in the mouse
2000, Archives of Ophthalmology
Apoptosis is a prominent feature of acute anterior uveitis in the Fischer 344 rat
2000, British Journal of Ophthalmology
Basic pathogenic mechanisms operating in experimental models of acute anterior uveitis
1998, Immunology and Cell Biology
Similar pattern of MCP-1 expression in spinal cords and eyes of Lewis rats with experimental autoimmune encephalomyelitis associated anterior uveitis
1997, Journal of Neuroscience Research

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Letter to the Editor
Letter to the Editor