Regular articleExpression of Fas-Fas Ligand Antigens and Apoptotic Marker APO2.7 by the Human Conjunctival Epithelium. Positive Correlation with Class II HLA DR Expression in Inflammatory Ocular Surface Disorders
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Conjunctival melanoma: New insights in tumour genetics and immunology, leading to new therapeutic options
2022, Progress in Retinal and Eye ResearchCitation Excerpt :The expression of these checkpoints in CoM is unknown, but may be relevant in cases that fail to respond against immunotherapy. Even so, Fas Ligand is a suppressor of immune activity and being expressed in conjunctival epithelium (Brignole et al., 1998), may contribute to CoM resistance against new therapies. Despite a limited number of studies on CoM, several conclusions can be drawn regarding the role of the immune infiltrate (Table 6).
HLA-DR expression as a biomarker of inflammation for multicenter clinical trials of ocular surface disease
2013, Experimental Eye ResearchCitation Excerpt :Since its introduction (Egbert et al., 1977), IC has been found to be useful in assessing the ocular surface in various ocular disorders such as dry eye/keratoconjunctivitis sicca (KCS; Wittpenn et al., 1986; Brignole et al., 2001), cicatricial ocular pemphigoid (Rivas et al., 2004), and vitamin A deficiency (McKelvie, 2003; Natadisastra et al., 1988) and has been used in clinical trials to evaluate HLA-DR expression in ocular surface diseases (Barabino et al., 2010; Mrugacz et al., 2007; Rolando et al., 2005; Baudouin et al., 2002; Brignole et al., 2000; Pisella et al., 2000; Tsubota et al., 1999; Baudouin et al., 1992, 1997). However, the reliability, reproducibility and storage limitations for the use of relative HLA-DR expression on IC-collected cells as a biomarker of inflammation for clinical trials has not yet been clearly established although there are several articles highlighting the uses of IC (Barabino et al., 2010; Baudouin et al., 1992, 1997, 2000; Brignole et al., 1998; Brignole et al., 2000; Brignole et al., 2001; Brignole-Baudouin et al., 2004a, 2004b; Calonge et al., 2004; Lopin et al., 2009; Fernandez et al., 2001; McKelvie, 2003; Natadisastra et al., 1987, 1988; Nelson et al., 1983; Puangsricharern and Tseng, 1995; Rolando et al., 2005; Roy et al., 2011; Singh et al., 2005; Stern et al., 2002; Stevenson et al., 2000; Thiel et al., 1997; Tole et al., 2001; Tseng, 1985. Tsubota et al., 1999; Wittpenn et al., 1986).
Immune response in the conjunctival epithelium of patients with dry eye
2010, Experimental Eye Research
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Correspondence to: C. Baudouin MD, PhD, Ambroise Paré Hospital, APHP, Department of Ophthalmology, 9 avenue Charles de Gaulle, 92104 Boulogne Cedex, France.