Regular articleHuman Conjunctiva Contains High Endothelial Venules That Express Lymphocyte Homing Receptors
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2012, Ocular SurfaceHoming of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease
2002, LancetCitation Excerpt :Extraintestinal complications that arise during an acute flare of inflammatory bowel disease could do so because circulating effector lymphocytes activated in the gut express high concentrations of adhesion molecules, such as LFA-1 and VLA-4, which promote recruitment of effector lymphocytes to tissues in which low concentrations of the endothelial ligands ICAM-1 and VCAM-1 are expressed. This mechanism could apply to the eye, a mucosal surface where increased expression of ICAM-1 and VCAM-1 has been recorded in people with uveitis,54,55 and where VAP-1, although not MAdCAM-1, has been detected in vessels similar to high endothelial venules in conjunctival follicles56 (figure 3). Arthropathy is the most common extraintestinal manifestation of inflammatory bowel disease, affecting up to 30% of people with this disorder.
Lymphocyte migration to inflamed lacrimal glands is mediated by vascular cell adhesion molecule-1/α<inf>4</inf>β<inf>1</inf> integrin, peripheral node addressin/L-selectin, and lymphocyte function-associated antigen-1 adhesion pathways
2001, American Journal of PathologyCitation Excerpt :MAdCAM-1 does not serve as an adhesion molecule in all mucosal lymphoid tissues, however. For example, HEV in several mucosal sites—including tonsil, bronchus-associated lymphoid tissues (BALT) (Xu, Butcher, and Michie, unpublished observation), nasal-associated lymphoid tissues, inflamed oral mucosa, and inflamed conjunctiva—fail to express functionally significant levels of MAdCAM-1.40–42 Although lacrimal glands are mucosal tissues, we did not find expression of MAdCAM-1 in normal or inflamed glands (Figure 3).
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Address correspondence to: Harminder Singh Dua, Department of Ophthalmology, Queen's Medical Centre, University Hospital, Nottingham, England, NG7 2UH, U.K.