Regular articleModulation of Choroidal Autoregulation in the Rabbit
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Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease
2022, Progress in Retinal and Eye ResearchCitation Excerpt :Deeper in the choroidal vasculature, neurons terminate at vascular smooth muscle cells and pericytes in the walls of arteries and veins, exerting contractile effects (Schrodl et al., 2014). Although a subject of controversy, intrinsic autoregulatory mechanisms within the choroid ‒ possibly acting as a myogenic response to local changes in intraluminal pressure ‒ may also play a role (Calzetti et al., 2018; Kiel, 1999; Nickla and Wallman, 2010; Reiner et al., 2018; Spaide, 2020). Finally, the vortex vein system has been suggested to function as a buffer, compensating for the pulsatile inflow of arterial blood into the choroid, in which the vascular systems are enclosed by the rigid sclera (Spaide, 2020).
Nitric oxide: a drug target for glaucoma revisited
2019, Drug Discovery TodayNeural control of choroidal blood flow
2018, Progress in Retinal and Eye ResearchCitation Excerpt :Given our anatomical data, it seems likely that neurogenic mechanisms contribute to ChBF regulation to BP fluctuation. Consistent with this, Kiel (1999) noted that both NOS inhibition and ganglionic blockade diminished the ChBF compensation to systemic hypotension in rabbit, implying some involvement of neurogenic vasodilatory mechanisms in the compensation. By contrast, ChBF compensation in piglet to perfusion pressure changes caused by IOP manipulation do not involve NO release, and thus seemingly at least in part involve a different mechanism than is involved in choroidal compensation for blood pressure fluctuations (Jacot et al., 1998).
Macular choroidal thickness in non-arteritic ischemic optic neuropathy
2016, Archivos de la Sociedad Espanola de OftalmologiaThe choroidal nervous system: a link between mineralocorticoid receptor and pachychoroid
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Address correspondence to: Jeffrey W. Kiel, Department of Ophthalmology, University of Texas Health Science Center, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900, U.S.A.