Elsevier

Genomics

Volume 20, Issue 2, 15 March 1994, Pages 317-319
Genomics

Short Communication
Mapping of the Autosomal Dominant Exudative Vitreoretinopathy Locus (EVR1) by Multipoint Linkage Analysis in Four Families

https://doi.org/10.1006/geno.1994.1176Get rights and content

Abstract

Autosomal dominant exudative vitreoretinopathy is a disorder affecting primarily the development of the human retinal vascular system. The disease locus has recently been assigned to 11q13-q23 by linkage studies in two families. Two-point analysis on a total of four families has now revealed close linkage (zmax = 8.34 at θ = 0.00) between the disease locus and D11S873. Multipoint linkage analysis mapped the disease locus between D11S527/D11S533 and D11S35 with a maximum lod score of over 11 directly at D11S873. No evidence appeared for genetic/linkage heterogeneity among the four families examined.

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