Regular ArticleM cells at locations outside the gut☆
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Cited by (91)
The bronchus-associated-lymphoid tissue (BALT) an unique lymphoid organ in man and animals
2022, Annals of AnatomyM cell targeting engineered biomaterials for effective vaccination
2019, BiomaterialsCitation Excerpt :Within different species, M cells have been proven to exist within the gut-associated lymphoid tissues (GALT), nasal-associated lymphoid tissues (NALT), the bronchus-associated lymphoid tissue (BALT), the conjunctiva-associated lymphoid tissue (CALT), the larynx-associated lymphoid tissue (LALT) and the lymphoid tissue associated with the tonsils (Fig. 2a) [68]. Table 1 summarizes the most commonly targeted areas and their associated challenges [26,30,69–75]. Although M cells are found in the many different lymphoid tissue mentioned above, the M cells in the GALT are the most studied and are believed to have a role in controlling GI tract infection and immunity.
Oral co-administration of a bacterial protease inhibitor in the vaccine formulation increases antigen delivery at the intestinal epithelial barrier
2019, Journal of Controlled ReleaseCitation Excerpt :Therefore, inhibition of proteolytic activity within enterocytes would contribute to protect the Ag during its transport across the epithelial barrier. This concept is supported by evidence that demonstrates that M cells -specialized in Ag transport at the intestinal epithelial surface- possess fewer lysosomes, indicating that a low intracellular antigen degradation ensures delivery of intact Ags to APCs at the lamina propria [22]. In this work we have demonstrated that U-Omp19 inhibits lysosomal cathepsin L activity inside live Caco-2 cells and promotes accumulation of Ag inside lysosomes of Caco-2 cells while does not change the intracellular fate of the co-administered Ag.
Nasal nanovaccines
2017, International Journal of PharmaceuticsCell-based in vitro models for intestinal permeability studies
2016, Concepts and Models for Drug Permeability Studies: Cell and Tissue based In Vitro Culture ModelsEvidence for a common mucosal immune system in the pig
2015, Molecular Immunology
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