Skip to main content
Log in

Three cases of EB virus-associated uveitis

  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

We report our experience with three cases of Epstein-Barr virus (EBV) - associated uveitis. These patients had the following common clinical features: 1) a common cold-like prodrome, 2) bilateral involvement, 3) severe acute anterior uveitis with fibrinous exudate, 4) granulomatous anterior uveitis in the chronic stage, 5) little vitreous inflammation, 6) marked hyperemia and edema of the disc, 7) sunset glow fundus developed very early, 8) a good response to steroids but recurrence was common, 9) good final visual acuity, 10) no systemic changes in the course of the uveitis.

High EBV IgG VCA antibody titers were found in the aqueous humor in all three cases (case 1,1:40; case 2,1: 160; case 3,1: 20). As controls, 37 cataract patients and 14 patients with various types of uveitis were examined for EBV antibodies in the aqueous humor. The result was negative in every case. On the basis of these data, the uveitis in these three patients appears to represent a new clinical entity: uveitis caused by EBV.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Depper JM, Zvaifler NJ. Epstein-Barr virus, its relationship to the pathogenesis of rheumatoid arthritis. Arthritis Rheum 1981; 24: 755–761.

    Google Scholar 

  2. Tanner OR. Ocular manifestations of infectious mononucleosis. Arch Ophthalmol 1952; 51: 229–241.

    Google Scholar 

  3. Wong KW, D'Amico DJ, Hedges TR III, Soong HK, Schooley RT, Kenyon KR. Ocular involvement associated with chronic Epstein-Barr virus disease. Arch Ophthalmol 1987; 105: 788–792.

    Google Scholar 

  4. Tiedeman JS. Epstein-Barr viral antibodies in multifocal choroiditis and panuveitis. Am J Ophthalmol 1987; 103: 659–663.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Usui, M., Sakai, J. Three cases of EB virus-associated uveitis. Int Ophthalmol 14, 371–376 (1990). https://doi.org/10.1007/BF00163559

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00163559

Key words

Navigation