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Lens fluorescence in relation to nephropathy in insulin-dependent diabetes mellitus

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Abstract

The relationship between diabetic nephropathy and blue-green lens fluorescence, lens transmittance, and other lens fluorometry parameters was studied in patients with long-term insulin-dependent diabetes mellitus. The findings in 10 patients who presented with diabetic nephropathy were compared with those of 11 patients of comparable age and duration of diabetes but without nephropathy. Diabetic nephropathy was associated with increased lens fluorescence (P=0.04) and decreased lens transmittance (P=0.045). We propose that lens changes may be responsible for various psychophysical abnormalities in diabetic patients and that our results explain the correlation of these abnormalities with the degree of microangiopathy.

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References

  1. Best JA van, Tjin A, Tsoi EWSJ, Boot JP, Oosterhuis JA (1985) In vivo assessment of lens transmission for blue-green light by autofluorescence measurement. Ophthalmic Res 17:90–95

    Google Scholar 

  2. Best JA van, Vrij L, Oosterhuis JA (1985) Lens transmission of blue-green light in diabetic patients as measured by autofluorophotometry. Invest Ophthalmol Vis Sci 26:532–536

    Google Scholar 

  3. Bleeker JC, Best JA van, Vrij L, Velde EA van der, Oosterhuis JA (1986) Autofluorescence of the lens in diabetic and healthy subjects by fluorophotometry. Invest Ophthalmol Vis Sci 27:791–794

    Google Scholar 

  4. Bresnick GH, Condit RC, Palta M, Korth K, Groo A, Syrjala S (1985) Association of hue discrimination loss and diabetic retinopathy. Arch Ophthalmol 103:1317–1324

    Google Scholar 

  5. Caroll RJ, Wu CFJ, Ruppert D (1987) The effects of estimating weights in generalized least squares. Technical Report 808. Department of Statistics, University of Wisconsin, Madison

    Google Scholar 

  6. Feingold KR, Lee TH, Chung MY, Siperstein MD (1986) Muscle capillary basement membrane width in patients with vacorinduced diabetes mellitus. J Clin Invest 78:102–107

    Google Scholar 

  7. Hanssen KF, Dahl-Jørgensen K, Lauritzen T, Feldt-Rasmussen B, Brinchmann-Hansen O, Deckert T (1986) Diabetic control and microvascular complications: the near-normoglycaemic experience. Diabetologia 29:677–684

    Google Scholar 

  8. Harding JJ, Dilley KJ (1976) Structural proteins of the mammalian lens: a review with emphasis on changes in development, aging and cataract. Exp Eye Res 22:1–73

    Google Scholar 

  9. Klang G (1948) Measurements and studies of the fluorescence of the human lens in vivo. Acta Ophthalmol (Copenh) 26: [Suppl. 31]

  10. Larsen M, Lund-Andersen H (1991) Lens fluorometry: light attenuation effects and estimation of total lens transmittance. Graefe's Arch Clin Exp Ophthalmol 229: 363–370

    Google Scholar 

  11. Larsen M, Kjer B, Bendtson I, Dalgaard P, Lund-Andersen H (1989) Lens fluorescence in relation to metabolic control of insulin-dependent diabetes mellitus. Arch Ophthalmol 107:59–62

    Google Scholar 

  12. Larsen M, Dalgaard P, Lund-Andersen H (1991) Determination of spatial coordinates in vitreous fluorometry. Graefe's Arch Clin Exp Ophthalmol 229:358–362

    Google Scholar 

  13. Lerman S, Kuck JF, Borkman RF, Saker E (1976) Induction, acceleration and prevention (in vitro) of an aging parameter in the ocular lens. Ophthalmic Res 8:213–226

    Google Scholar 

  14. Lerman S, Megaw JM, Moran MN (1985) Further studies on the effects of UV radiation on the human lens. Ophthalmic Res 17:354–361

    Google Scholar 

  15. Mauer SM, Steffes MW, Connett J, Najarian JS, Sutherland DER, Barbosa J (1983) The development of lesions in the glomerular basement membrane and mesangium after transplantation of normal kidneys to diabetic patients. Diabetes 32:948–952

    Google Scholar 

  16. Monnier VM, Cerami A (1981) Nonenzymatic browning in vivo: possible process for aging of long-lived proteins. Science 211:491–493

    Google Scholar 

  17. Mosier MA, Occhipinti JR, Burstein NL (1986) Autofluorescence of the crystalline lens in diabetes. Arch Ophthalmol 104:1340–1343

    Google Scholar 

  18. Occipinti JR, Mosier MA, Burstein NL (1986) Autofluorescence and light transmission in the aging crystalline lens. Ophthalmologica 192:203–209

    Google Scholar 

  19. Sosenko JM, Miettinen OS, Williamson JR, Gabbay KH (1984) Muscle capillary basement-membrane thickness and long-term glycemia in type 1 diabetes mellitus. N Engl J Med 311:694–698

    Google Scholar 

  20. Wirdum E van, Mota MC, Best JA van, Leite E, Kappelhof JP, Abreu JRF de, Martins JF, Oosterhuis JA, Marques A (1984): Lens transmission and autofluorescence in renal disease. Ophthalmic Res 16:246–255

    Google Scholar 

  21. Zeimer RC, Noth JM (1984) A new method of measuring in vivo the lens transmittance, and study of lens scatter, fluorescence and transmittance. Ophthalmic Res 16:246–255

    Google Scholar 

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All legal requirements governing consent were met for this study. The authors have no proprietary or financial interest in the Fluorotron or in Coherent, Inc.

Offprint requests to: M. Larsen

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Larsen, M., Kjer, B., Bendtson, I. et al. Lens fluorescence in relation to nephropathy in insulin-dependent diabetes mellitus. Graefe's Arch Clin Exp Ophthalmol 230, 6–10 (1992). https://doi.org/10.1007/BF00166755

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  • DOI: https://doi.org/10.1007/BF00166755

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