Summary
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1.
Botulinum toxin type A was injected into gastrocnemius muscles of cats and 2 days later its action on the monosynaptic gastrocnemius reflex and on the recurrent inhibition was investigated.
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2.
In early local botulism, no significant change in the monosynaptic gastrocnemius reflex was observed.
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3.
The inhibition by antidromic stimulation of the monosynaptic gastrocnemius reflex was significantly reduced.
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4.
During the early phases of local botulism an action of botulinum toxin on parts of the soma membrane of the α-motoneuron is suggested.
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This work was supported by grant No. We 479/4 from the Deutsche Forschungsgemeinschaft. A preliminary communication was presented at the 1974 spring meeting of the Deutsche Pharmakologische Gesellschaft (Wiegand and Wellhöner, 1974)
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Wiegand, H., Wellhöner, H.H. The action of botulinum A neurotoxin on the inhibition by antidromic stimulation of the lumbar monosynaptic reflex. Naunyn-Schmiedeberg's Arch. Pharmacol. 298, 235–238 (1977). https://doi.org/10.1007/BF00500893
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DOI: https://doi.org/10.1007/BF00500893