Summary
The spread of HSV of type 1 and 2 was investigated after intraperitoneal, intraplantar and intracerebral infections of resistant (C57/bl) and susceptible (NMRI) mice. The virus spreads after i.p. infection to the spleen and the liver to the same extent in both strains of mice. However, virus is eliminated earlier in resistant mice. Intracerebral infections revealed a peculiar type of resistance of C57/bl mice especially for type 2 of HSV. HSV multiplies in the thymus at the early stage of infection and can be detected in this organ in sick mice of NMRI strain. HSV-1 and 2 can be detected in the spinal cord of C57/bl mice without sickness or death of these animals.
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Bräutigam, A. R., Dutko, F. J., Olding, L. B., Oldstone, M. B. A.: Pathogenesis of murine cytomegalovirus infection: The Macrophage as a permissive cell for cytomegalovirus infection, replication and latency. J. gen. Virol.44, 349–359 (1979).
Burns, W. H., Billups, L. C., Notkins, A. C.: Thymus dependence of viral antigens. Nature256, 654–656 (1975).
Dundarov, S., Schorlemmer, H. U., Falke, D.: In preparation (1980).
Dundarov, S., Falke, D.: Thymidine-, Uridine- and Choline-Kinase in rabbit kidney cells infected with Herpesvirus hominis, type I and II. Arch. Virol.38, 56–66 (1972).
Frank, U., Schindling, B., Lindermann, J., Falke, D.: Multiplication of HSV types 1 and 2 in macrophages of NMRI and C 57/bl mice. Acta Virol.22, 193–202 (1978).
Frank, U., Caspary, L., Hahn, H., Falke, D.: The effect of Dextransulfate 500 on the pathogenesis of Herpes simplex virus infections in weanling mice. Arch. Virol.58, 259–268 (1978).
Grodums, E. I., Zbitnew, A.: Experimental Herpes simplex virus carditis in mice. Infect. Immun.14, 1322–1331 (1976).
Higgins, D. A., Calneck, B. W.: Some effects of Silica treatment on Marek Disease. Infect. Immun.13, 1054–1060 (1976).
Johnson, R. T.: The pathogenesis of Herpesvirus encephalitis. II. A cellular basis for the development of resistance with age. J. exp. Med.120, 359–371 (1964).
Kirchner, H., Hirt, H. M., Kleinicke, C., Munk, K.: Replication of HSV in mouse spleen cell cultures stimulated by Lipopolysaccharide. J. Immunol.117, 1753–1756 (1976).
Kirchner, H., Hirt, H., Rosenstreich, D., Mergenhagen, S.: Resistance of C3H/HeJ mice to lethal challenge with HSV. Proc. Soc. exp. Biol. Med.157, 29–32 (1978).
Kirchner, H., Zawatzky, R., Hirt, H. M.:In vitro production of immune Interferon by spleen cells of mice immunized with Herpes simplex virus. Cell. Immunol.40, 204–210 (1978).
Kirchner, H., Kochen, M., Hirt, H. M., Munk, K.: Immunological studies of HSV-infection of resistant and susceptible inbred strains of mice. Z. Immun.-Forsch.154, 147–154 (1978).
Kohlhage, H., Siegert, R.: Zwei genetisch determinierte Varianten eines Herpessimplex-Stammes. Arch. ges. Virusforsch.12, 273–286 (1962).
Lausch, R. N., Swyers, J. S., Kaufman, H. E.: Delayed type hypersensitivity to HSV in the guinea pig. J. Immunol.96, 981–987 (1966).
Lindenmann, J., Lane, C., Hobson, D.: The resistance of A 2G mice to myxoviruses. J. Immunol.90, 942–951 (1963).
Lodmell, D. L., Notkins, A. L.: Cellular immunity to HSV mediated by interferon. J. exp. Med.140, 764–778 (1974).
Lopez, C.: Genetics of natural resistance to Herpesvirus infections in mice. Nature258, 152–153 (1975).
Lopez, D., Dudas, G.: Replication of HSV type 1 in macrophages from resistant and susceptible mice. Infect. Immun.23, 422–437 (1979).
McGeorge, M. B., Morahan, P. S.: Comparison of various macrophage inhibitory agents on vaginal and systemic HSV type 2 infections. Infect. Immun.22, 623 to 626 (1978).
Mogensen, S. C.: Genetics of macrophage controlled resistance to Hepatitis induced by Herpes simplex virus type 2 in mice. Infect. Immun.17, 268–273 (1977).
Mogensen, S. C., Andersen, H. K.: Effect of Silica on the pathogenic distinction between Herpes simplex virus type 1 and 2 Hepatitis in mice. Infect. Immun.17, 274–277 (1977).
Morahan, P. S., Morse, S. S., McGeorge, M. B.: Macrophage extrinsic antiviral activity during HSV infection. J. gen. Virol.46, 291–300 (1980).
Pfizenmaier, K., Starzinski-Powitz, A., Röllinghoff, M., Falke, D., Wagner, H.: T-cell mediated cytotoxicity against Herpes simplex virus infected target cells. Nature265, 630–632 (1977).
Roger-Zismann, B., Allison, A. C.: Mechanism of immunologic resistance on Herpes simplex 1 (HSV-1)-infection. J. Immunol.116, 35–40 (1976).
Selgrade, M., Osborn, J.: Role of macrophages in resistance to murine cytomegalovirus. Infect. Immun.10, 1383–1390 (1974).
Sethi, K. K., Brandis, H.:In vitro acquisition of resistance against HSV by permissive murine macrophages. Arch. Virol.59, 157–172 (1979).
Schell, K.: Studies on the innate resistance of mice to infection with mousepox: I. Resistance and antibody production. Austr. J. exp. Biol. Med. Sci.38, 271–288 (1960).
Schindling, B.: Thesis, Mainz, 1979.
Schlabach, A. J., Martinez, D., Field, A. K., Tytell, A. A.: Resistance of C58 mice to primary systemic Herpes simplex virus infection: Macrophage dependence and T-cell independence. Infect. Immun.26, 615–620 (1979).
Stevens, J. G., Cook, M. L.: Restriction of HSV by macrophages. J. exp. Med.133, 19–36 (1971).
Tosolini, F., Mims, C.: Effect of murine strain and viral strain on the pathogenesis of lymphocytic choriomeningitis infection and a study of footpad responses. J. inf. Dis.123, 134–144 (1971).
Zawatzky, R., Hilfenhaus, J., Kirchner, H.: Resistance of nude mice to Herpes simplex virus and correlation within vitro production of interferon. Cell. Immunol.47, 424–428 (1978).
Zisman, B., Hirsch, M. S., Allison, A. C.: Selective effects of antimacrophage serum, silica and antilymphocyte serum on pathogenesis of herpes virus infection of young adult mice. J. Immunol.104, 1155–1159 (1970).
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With 2 Figures
In partial fulfilment of the requirements for the MD degree.
Fellow from the Alexander von Humboldt-Stiftung.
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Caspary, L., Schindling, B., Dundarov, S. et al. Infections of susceptible and resistant mouse strains with herpes simplex virus type 1 and 2. Archives of Virology 65, 219–227 (1980). https://doi.org/10.1007/BF01314538
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DOI: https://doi.org/10.1007/BF01314538