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The choroid: from the architect gene to apoptosis

Lecture on acceptance of the Hermann Wacker Prize 1996

  • Club Jules Gonin
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Conclusion

Since Aristotle, all sciences are founded on the concern for rationality which lies behind all biological research. Our time corresponds to an epistemological disruption which strives to understand. Laplacian determinism is giving way to a probability vision. The complexity of problems always defies the possibilities of calculation. One should ask whether the conception of the randomness of organization is essential, or simply the result of our ignorance of causes.

In the next 40 years, or perhaps even in the next 10 years, essentially all human genes will have been discovered, sequenced and listed in order. However, the greatest challenge is not to discover genes and their significance, but to analyse their function. Maybe the sciences of the nervous system, the sciences of the brain, cognitive psychology and the sciences of the mind will be unified. Is there a molecular biology of knowledge?

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  • Amalric P (1963) Le territoire chorio-rétinien de l'artére ciliare longue postérieure. Etude clinique. Bull Soc Fr 342–351 [first description of triangular syndrome]

  • Amalric P (1972) A propos des syndromes ovalaires — étude topographique du réseau vasculaire choroidien au niveau de la macula. Société Francaise d'Ophthalmologie, Paris, 8 May

    Google Scholar 

  • Amalric P (1972) Choroidal vessel occlusive syndromes: clinical aspects. American Academy of Ophthalmology and Otolaryngology, Dallas, 24–28 September

    Google Scholar 

  • Amalric P (1974) Veines choroidiennes — état normal et pathologique. Ann Occul 207:161–183

    Google Scholar 

  • Amalric P (1996) The macular choroid and its developments at the embryological stage. Presented at 4th Meeting of European Macula Group, Genoa, Italy, 31 May – 1 June

  • Cook TA (1979) The curves of life. Dover, New York

    Google Scholar 

  • Duke-Elder S (1962) The principles of heredity. In: System of ophthalmology, vol VII, The foundations of ophthalmology. Kimpton, London, pp 3–30

    Google Scholar 

  • Fryckzowski AW (1988) Angioarchitecture of the human submacular choroid. Acta Anat 132:165–169

    Google Scholar 

  • Gehring WJ (1996) The master control gene for morphogenesis and evolution of the eye. Genes Cells 1:11–15

    PubMed  Google Scholar 

  • Halder G, Callaerts P, Gehring WJ (1995) New perspectives on eye evolution. Curr Opin Genet Dev 5:602–609

    PubMed  Google Scholar 

  • Halder G, Callaerts P, Gehring WJ (1995) Induction of ectopic eyes by targeted expression of the eyeless gene inDrosophila. Science 267:1788–1792

    PubMed  Google Scholar 

  • Heimann K (1978) The choroidal vascular system. Proceedings of XXIIIth Concilium Ophthalmologicum, Kyoto, Japan. International Congress Series, p 222

  • Horgan J (1995) From complexity to perplexity. Sci Am June:74–79

  • Olver JM (1990) Functional anatomy of the choroidal circulation: Methyl methacrylate casting of human choroid. Eye 4:262–272

    PubMed  Google Scholar 

  • Papermaster DS (1995) Death at an early age. Apoptosis in inherited degeneration. Invest Ophthalmol Vis Sci 36:977–983

    PubMed  Google Scholar 

  • Polyak SL (1941) The retina. University of Chicago Press, Chicago

    Google Scholar 

  • Shimizu K, Ujiie K (1978) Structure of ocular vessels. Igaku Shoin, Tokyo

    Google Scholar 

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Amalric, P. The choroid: from the architect gene to apoptosis. Graefe's Arch Clin Exp Ophthalmol 235, 675–683 (1997). https://doi.org/10.1007/BF01880665

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