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The pattern-evoked electroretinogram (PERG): Age-related alterations and changes in glaucoma

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Abstract

Pattern-onset electroretinograms (PERGs) were studied in 147 normal subjects of different ages (14–79 years) and in 110 eyes of 65 patients with glaucoma or ocular hypertension. The responses showed an increase (P < 0.001) in peak latency with increasing age and a decrease (P < 0.001) in amplitude which approximately parallels the loss of ganglion cells estimated by other authors. Many glaucoma eyes showed a loss of the normally present spatial tuning. In the age group above 50 years 50% of the onset responses were significantly diminished and the peak latencies were not significantly different. A negative correlation (P < 0.001) was found between the size of the PERG and the cup/disc ratio and a positive correlation (P < 0.001) with the area of the neuroretinal rim of the optic disc. The PERG decreased (P < 0.01) with increasing visual field losses.

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Authors and Affiliations

  1. Augenklinik der Universität, Schwabachanlage 6, D-8520, Erlangen, Federal Republic of Germany

    Matthias Korth, Folkert Horn, Brigitte Storck & Jost Jonas

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  1. Matthias Korth
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  4. Jost Jonas
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Korth, M., Horn, F., Storck, B. et al. The pattern-evoked electroretinogram (PERG): Age-related alterations and changes in glaucoma. Graefe's Arch Clin Exp Ophthalmol 227, 123–130 (1989). https://doi.org/10.1007/BF02169783

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  • DOI: https://doi.org/10.1007/BF02169783

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