Skip to main content
Log in

Corneal perforation in Mooren's ulcer — immunological and clinical follow-up

  • Clinical Investigations
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

A case of corneal perforation in a patient found to have Mooren's ulcer is presented. The patient was followed up for 1 year both before and after perforation. No evidence of accompanying systemic disease was found. The ulcer healed after excision of the limbal conjunctiva. The subepithelial layer of the conjunctiva was packed with plasma cells. Both IgG and IgM were found in the epithelium as well as along the small vessels. The T-lymphocyte subpopulation was examined three times during the course of the disease; an inverse ratio was always found between the helper and suppressor/cytotoxic T cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Brown SI, Bertley J, Mondino M, Rabin BS (1976) Autoimmune phenomena in Mooren's ulcer. Am J Ophthalmol 82: 835–840

    Google Scholar 

  2. Diamond BA, Yelton DE, Scharff MD (1981) Monoclonal antibodies — a new technique for reproducing serological reagents. N Engl Med 304: 1344–1349

    Google Scholar 

  3. Duke-Elder S (1965) System of opthalmology, vol VII. Kimpton, London, p 918

    Google Scholar 

  4. Foster CS, Kenyon KR, Greiner J, Greineder DK (1979) The immunopathology of Mooren's ulcer. Am J Ophthalmol 88: 149–159

    Google Scholar 

  5. Murray PI, Rahi AHS (1985) New concepts in the control of ocular inflammation. Trans Ophthalmol Soc UK 104: 152–158

    Google Scholar 

  6. Valenzuela R, Deodhar SD (1986) Tissue immunofluorescence. In: Rose NR (ed) Manual of clinical laboratory immunology, 3rd edn. American Society of Microbiology, pp 923–925

  7. Wilson FM, Grason M, Ellis FD (1976) Treatment of peripheral corneal ulcers by limbal conjunctivectomy. Br J Ophthalmol 60: 713–715

    Google Scholar 

  8. Winchester RJ, Rose GD (1986) Methods for enumerating cell populations with a conventional microscope. In: Rose NR (ed) Manual of clinical and laboratory immunology, 3rd edn. American Society of Microbiology, pp 212–225

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Parunović, A., Brkić, S. & Vučković, S. Corneal perforation in Mooren's ulcer — immunological and clinical follow-up. Graefe's Arch Clin Exp Ophthalmol 226, 330–331 (1988). https://doi.org/10.1007/BF02172961

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02172961

Keywords

Navigation