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Ultrastructural alterations in rat and cat retina and pigment epithelium induced by chloroquine

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Abstract

Chloroquine retinopathy in rats and cats was studied (in long-term experiments on rats the drug was injected into the stomach). We observed the slow development of the pathological process, accompanied by the appearance of membrane inclusions in GC, structural alterations in the RPE, and after 10 months complete destruction of the outer segments of the photoreceptors. In experiments on cats, after a single intravitreous chloroquine injection destruction of the photoreceptors, similar to that observed in rats, was found 2 weeks after the injection. In the region of tapetum nigrum containing melanin photoreceptors were safe. These data suggest the protective effect of melanin on the process of chloroquine retinopathy.

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References

  • Abraham R, Hendy R (1970) Irreversible lysosomal damage induced by chloroquine in the retinae of pigmented and albino rats. Exp Mol Pathol 12: 185–200

    CAS  PubMed  Google Scholar 

  • Arden GB, Kolb H (1966) Antimalarial therapy and early retinal changes in patients with rheumatoid arthritis. Br Med J 1: 270–273

    Google Scholar 

  • Bernstein HN, Zvaifler N, Rubin M, Mansourt A (1963) The ocular deposition of chloroquine. Invest Ophthalmol 2: 384–392

    CAS  PubMed  Google Scholar 

  • Bernstein HN, Ginsberg J (1964) Pathology of chloroquine retinopathy. Arch Ophthalmol 71: 238–245

    CAS  PubMed  Google Scholar 

  • Berson CA (1970) Acute toxic effects of chloroquine on the cat retina. Invest Ophthalmol 9: 618–628

    CAS  PubMed  Google Scholar 

  • Drenckhahn D, Lülmann-Rauch R (1978) Drug-induced retinal lipidosis: differential susceptibilities of pigment epithelium and neuroretina toward several amphiphilic cationic drug. Exp Mol Pathol 28: 360–371

    Article  CAS  PubMed  Google Scholar 

  • Elman A, Gulliberg AER, Nilsson E, Rendahe J, Wachtmerster, L (1976) Chloroquine retinopathy in patients with rheumatoid arthritis. Scand J Rheumatol 5: 161–166

    CAS  PubMed  Google Scholar 

  • François J, Maudgal C (1967) Experimentally induced chloroquine retinopathy in rabbits. Am J Ophthalmol 64: 886–892

    PubMed  Google Scholar 

  • Gleiser CA, Dukes TW, Lawwie T, Reed WK, Bay WW, Brown RS (1969) Ocular changes in swine associated with chloroquine toxity. Am J Ophthalmol 67: 399–405

    CAS  PubMed  Google Scholar 

  • Henkind P, Rothfield NF (1963) Ocular abnormalities in patients treated with synthetic antimalarial drugs. New Engl J Med 269: 433–439

    CAS  PubMed  Google Scholar 

  • Hodgkinson BJ, Kolb H (1970) A preliminary study of the effect of chloroquine on the rat retina. Arch Ophthalmol 84: 509–515

    CAS  PubMed  Google Scholar 

  • Ivanina TA, Lebedeva MN (1982) Electronmicroscopical and electrophysiological investigation of the effects of the antimalarial drugs dabequine and chloroquine on the rat retina. Med Parazitol (Mosk) (in Russian) (in press)

  • Kuhn H, Steiger A (1981) Structural alterations of Tapetal cells in the retina of cats induced by prolonged treatment with chloroquine. Cell Tissue Res 215: 263–269

    Article  CAS  PubMed  Google Scholar 

  • Kuhn H, Keller P, Kovács E, Steiger A (1981) Lack of correlation between melanin affinity and retinopathy in mice and cats treated with chloroquine or flunitrazepam. Albrecht von Graefes Arch Klin Ophthalmol 216: 177–190

    Article  CAS  Google Scholar 

  • Meier-Ruge W (1965) Experimental investigation of morphogenesis of chloroquine retinopathy. Arch Ophthalmol 73: 540–545

    CAS  PubMed  Google Scholar 

  • Ramsay MS, Fine BS (1972) Chloroquine toxity in the human eye histopathologic observation by electron microscopy. Am J Ophthalmol 73: 229–235

    Google Scholar 

  • Rosenthal AK, Kolb H, Bergsma D, Huxsoll D, Hopkins JL (1978) Chloroquine retinopathy in the rhesus monkey. Invest Ophthalmol 17: 1158–1178

    CAS  Google Scholar 

  • Sherbel AL, Makenzre AH, Maisek IE, Housek IA, Atdjran M (1965) Ocular lesions in rheumatoid arthritis and related disorders with particular reference to retinopathy. A study of 741 patients treated with and without chloroquine drugs. New Engl J Med 273: 360–366

    Google Scholar 

  • Smith RS, Berson EL (1971) Acute toxic effects of chloroquine on the cat retina: ultrastructural changes. Invest Ophthalmol 10: 237–246

    CAS  PubMed  Google Scholar 

  • Wetterholm DH, Winter FC (1964) Histopathology of chloroquine retinal toxity. Arch Ophthalmol 71: 82–87

    CAS  PubMed  Google Scholar 

  • Yamagishi N, Nagata M (1979) Chloroquine in human ocular tissues. Acta Soc Ophthalmol Jpn 83: 865–873

    CAS  Google Scholar 

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Authors and Affiliations

  1. Helmholtz Institute of Ophthalmology, Sadovaja-Chernogriasskaya 14/19, Moscow, USSR

    T. A. Ivanina, M. V. Zueva, M. N. Lebedeva, A. I. Bogoslovsky & A. J. Bunin

  2. Martsinovsky Institute for Medical Parasitology and Tropical Medicine, Moscow, USSR

    T. A. Ivanina, M. V. Zueva, M. N. Lebedeva, A. I. Bogoslovsky & A. J. Bunin

Authors
  1. T. A. Ivanina
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  2. M. V. Zueva
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  3. M. N. Lebedeva
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  4. A. I. Bogoslovsky
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  5. A. J. Bunin
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Additional information

This work is part of research project 790555, which receives financial support from the UNDP/World Bank/WHO Special Program for Research and Training in Tropical Diseases

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Ivanina, T.A., Zueva, M.V., Lebedeva, M.N. et al. Ultrastructural alterations in rat and cat retina and pigment epithelium induced by chloroquine. Graefe's Arch Clin Exp Ophthalmol 220, 32–38 (1983). https://doi.org/10.1007/BF02307013

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  • DOI: https://doi.org/10.1007/BF02307013

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