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Cone and rod ERGs in degenerations of central retina

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Abstract

Sixty-four patients with retinal degenerations at the posterior pole were reviewed and their ERGs analysed. On the basis of symptoms, visual acuity, ophthalmoscopy and cone/rod ERG the patients were divided into five diagnostic groups: Stargardt's disease, fundus flavimaculatus, cone degeneration, dominant drusen and central retinitis pigmentosa (RP). Stargardt's disease and fundus flavimaculatus show low-normal or subnormal cone b-wave amplitudes, often with prolonged peak times; the rod ERG is rarely abnormal. Cone degeneration presents with reduced visual acuity, photophobia, nystagmus and minimal fundus changes. The ERG shows severely reduced cone b-waves and increased peak times; the rod b-waves are in the low-normal or subnormal range. Dominantly inherited drusen, included for comparison, revealed little change in the ERG in spite of widespread ophthalmoscopic changes: b-wave amplitudes fall mostly in the low-normal range, and their peak times may be prolonged. RP of the central type reveals considerable variability in all clinical aspects, but the cone and rod ERGs are consistently greatly reduced, showing markedly increased peak times of the cone b-waves. Recording of the Ganzfeld ERG with cone/rod separation thus proves useful in differentiating degenerations of the central retina.

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References

  • Babel J, Stangos N, Korol S, Spiritus M (1977) Ocular electrophysiology. Georg Thieme, Stuttgart

    Google Scholar 

  • Berson EL, Gouras P, Gunkel RD (1968a) Rod responses in retinitis pigmentosa, dominantly inherited. Arch Opthalmol 80: 58–67

    CAS  Google Scholar 

  • Berson EL, Gouras P, Gunkel RD (1968b) Progressive cone-rod degeneration. Arch Ophthalmol 80: 68–76

    CAS  Google Scholar 

  • Berson EL, Gouras P, Gunkel RD (1968c) Progressive cone degeneration, dominantly inherited. Arch Ophthalmol 80: 77–87

    CAS  Google Scholar 

  • Carr RE, Siegel IM (1982) Visual electrodiagnostic testing: a practical guide for the clinician. Williams and Wilkins, Baltimore

    Google Scholar 

  • Deutman A (1971) The hereditary dystrophies of the posterior pole of the eye. Van Gorcum and Co., Assen, pp 35–41, 172–180

    Google Scholar 

  • Deutman A (1974) Macular dystrophies. In: Goldberg MF (ed) Genetic and metabolic eye disease. Little, Brown and Co., Boston, pp 367–429

    Google Scholar 

  • Dušek J. Streicher T, Schmidt R (1982) Hereditäre Drusen der Bruch'schen Membran. II. Untersuchung von Semidünnschnitten und elektronenmikroskopischen Ergebnissen. Klin Monatsbl Augenheilkd 18: 79–83

    Google Scholar 

  • Farkas T, Sylvester V, Archer D (1971) The ultrastructure of drusen. Am J Opthalmol 71: 1196–1205

    CAS  Google Scholar 

  • Fishman GA (1976a) Fundus flavimaculatus: a clinical classification. Arch Ophthalmol 94: 2061–2067

    CAS  PubMed  Google Scholar 

  • Fishman GA (1976b) Progressive human cone-rod dysfunction (dystrophy). Trans Am Acad Ophthalmol Otolaryngol 81: 716–724

    Google Scholar 

  • Forni S, Babel J (1962) Etude clinique et histologique de la malattia leventinese. Opthalmologica 143: 313–321

    CAS  Google Scholar 

  • Franceschetti A, François J (1965) Fundus flavimaculatus. Arch Ophthalmol (Paris) 25: 505–530

    CAS  Google Scholar 

  • Franceschetti A, François J, Babel J (1974) Chorioretinal heredodegenerations. Charles C. Thomas, Springfield, Illinois, pp 275–289

    Google Scholar 

  • Goodman G, Ripps H, Siegel IM (1966) Progressive cone degeneration. In: Burian HM, Jacobson JH (eds) Clinical electroretinography, Proc. IIIrd ISCERG Symp. Pergamon Press, New York, p 363

    Google Scholar 

  • Gouras P (1970) Electroretinography: some basic principles. Invest Ophthalmol 9: 557–569

    CAS  PubMed  Google Scholar 

  • Gurewitsch K, Niemeyer G (1982) Rod/cone separation by electroretinography, fundus changes and visual fields in retinitis pigmentosa. In: Niemeyer G, Huber CH, (eds) XIXth ISCEV Symposium. Doc Ophthalmol Proc. Series 31: 145

    Google Scholar 

  • Hadden OB, Gass JDM (1976) Fundus flavimaculatus and Stargardt's disease. Am J Ophthalmol 82: 527–539

    CAS  PubMed  Google Scholar 

  • Hatt M, Niemeyer G (1976) Electroetinographie bei Morbus Behçet. Graefe's Arch Clin Exp Ophthalmol 198: 113–120

    CAS  Google Scholar 

  • Hess F, Niemeyer G (1983) EOG changes in dominantly inherited drusen (Malattia leventinese). XXth ISCEV Symposium, Iowa City, Oct 1982, Doc Ophthalmol Proc Series, in press

  • Hittner HM, Murphree AL, Garcia CA, Justice J, Chokshi DB (1975) Dominant cone-rod dystrophy. Doc Ophthalmol 39: 29–52

    Article  CAS  PubMed  Google Scholar 

  • Irvine AR, Wergeland FL (1972) Stargardt's hereditary progressive macular degeneration. Br J Ophthalmol 56: 817–826

    CAS  PubMed  Google Scholar 

  • Jaeger W, Alexandridis E, Kraus E, Tenner A, Käfer O (1975) Hereditäre Makuladegenerationen. DOG 1973; Bergmann, Berlin, pp 695–735

    Google Scholar 

  • Jaeger W, Krastel H, Blankenagel A (1979) Zur Symptomatik der Zapfendystrophie. Ber Zusammenkunft Dtsch Ophthalmol Ges 76: 397–408

    Google Scholar 

  • Klien BA, Krill AE (1967) Fundus flavimaculatus: clinical functional and histopathological observations. Am J Ophthalmol 64: 3–23

    CAS  PubMed  Google Scholar 

  • Krill AE (1977) Hereditary retinal and choroidal diseases, vol 2. Clinical characteristics. Harper and Row, Hagerstown

    Google Scholar 

  • Krill AE, Deutman AF (1972) Dominant macular degenerations. The cone dystrophies. Am J Ophthalmol 73: 352–369

    CAS  PubMed  Google Scholar 

  • Krill AE, Deutman AF, Fishman M (1973) The cone degenerations. Doc Ophthalmol 35: 1–80

    Article  CAS  PubMed  Google Scholar 

  • Krill AE, Klien BA (1965) Flecked retina syndrome. Arch Ophthalmol 74: 496–508

    CAS  PubMed  Google Scholar 

  • Niemeyer G (1969) Electroretinographie bei Maculadegenerationen. Graefe's Arch Clin Exp Ophthalmol 177: 39–51

    CAS  Google Scholar 

  • Niemeyer G (1976) Stäbchen- und Zapfenaktivität im klinischen Elektroretinogramm. Ophthalmologica 172: 175–180

    CAS  PubMed  Google Scholar 

  • Niemeyer G (1978) Rod- and cone-function in Malattia leventinese and in retinitis pigmentosa. Doc Ophthalmol Proc Series 17: 337–344

    Google Scholar 

  • Niemeyer G (1979) Information von der Netzhaut durch Elektroretinographie. Graefe's Arch Clin Exp Ophthalmol 211: 129–137

    CAS  Google Scholar 

  • Niemeyer G, Gurewitsch K (1982) Variabilität von Visus, Dunkel-adaptation und Elektroretinogramm bei Retinitis pigmentosa. Klin Monatsbl Augenheilkd 180: 401–404

    CAS  PubMed  Google Scholar 

  • Noble KG, Carr RE (1979) Stargardt's disease and fundus flavimaculatus. Arch Ophthalmol 97: 1281–1285

    CAS  PubMed  Google Scholar 

  • Pearlman JT, Owen WG, Brounley DW, Sheppard JJ (1974) Cone dystrophy with dominant inheritance. Part 1: Clinical case histories. Part 2: Special colour vision tests. Doc Ophthalmol Proc Series, XIth ISCERG Symp, Dr W Junk Publishers, The Hague, pp 113–122, 123–125

    Google Scholar 

  • Pinckers A, Deutman AF (1977) Peripheral cone disease. Ophthalmologica 174: 145–150

    CAS  PubMed  Google Scholar 

  • Scarpatetti A, Forni S, Niemeyer G (1978) Die Netzhautfunktion bei Malattia leventinese (dominant drusen). Klin Monatsbl Augenheilkd 172: 590–597

    CAS  PubMed  Google Scholar 

  • Skalka HW (1978): Electrophysiological variability in fundus flavimaculatus. In: Tazawa Y (ed) Proc. 16th ISCEV Symp. Jpn J Ophthalmol, Tokyo, Japan 75–79

    Google Scholar 

  • Streicher T, Schmidt K, Dusek J (1982) Hereditäre Drusen der Bruch'schen Membran. I. Klinische und lichtmikroskopische Beobachtungen. Klin Monatsbl Augenheilkd 181: 27–31

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Universitätsspital, CH-8091, Zürich, Switzerland

    G. Niemeyer & E. Demant

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  1. G. Niemeyer
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  2. E. Demant
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Niemeyer, G., Demant, E. Cone and rod ERGs in degenerations of central retina. Graefe's Arch Clin Exp Ophthalmol 220, 201–208 (1983). https://doi.org/10.1007/BF02308075

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  • DOI: https://doi.org/10.1007/BF02308075

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