Abstract
Background
We evaluated, in a nonrandomised, institutional, prospective study, the efficacy of photodynamic therapy (PDT) with verteporfin in age-related macular degeneration (AMD) eyes with polypoidal choroidal vasculopathy (PCV) and subfoveal exudation.
Methods
A prospective clinical and angiographic study was done in 40 consecutive eyes with PCV treated with PDT using masked best-corrected visual acuity (VA) and fluorescein and indocyanine green angiographic features at baseline and over 2 years.
Results
Twenty-one eyes completed 1-year follow-up and showed, after a mean 2.9 PDT sessions, VA improvement in 12 eyes, no change in five eyes, and VA decrease in four eyes. Leakage was absent at the retinal and choroidal level in 14 eyes at 1 year. Recurrence occurred in one eye during the first year. Six eyes completed 2 years of follow-up and showed, after a mean 4 PDT sessions, VA improvement in five eyes and VA decrease in one eye. Leakage was absent at the retinal and choroidal level in five eyes. Recurrence occurred in four of these six eyes during the second year of follow-up. No serious adverse events were observed during the 2 years of follow-up.
Conclusions
PDT with verteporfin was shown to be safe and effective for treating AMD eyes with PCV with subfoveal involvement. VA improvement and absence of leakage were achieved, respectively, in 57.1% and 66.6% of the eyes at 1 year. Recurrences were more frequent during the second year of follow-up.
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References
Chan WM, Lam DSC, Lai TYY, Liu DTL, Li KKW, Yao Y, Wong TH (2004) Photodynamic therapy with verteprofin for symptomatic polypoidal choroidal vasculopathy. Ophthalmology 111:1576–1584
Ciardella AP, Donsoff IM, Huang SJ, Costa DL, Yannuzzi LA (2004) Polypoidal choroidal vasculopathy. Surv Ophthalmol 49:25–37
Guyer DR, Yannuzzi LA, Slakter JS, Sorenson JA, Hope-Ross M, Orlock DR (1994) Digital indocyanine-green video angiography of occult choroidal neovascularisation. Ophthalmology 101:1727–1737
Kwok AK, Lay TY, Chan CW, et al. (2002) Polypoidal choroidal vasculopathy in Chinese patients. Br J Ophthalmol 86:892–897
Lafaut BA, Leys AM, Snyers B, et al. (2000) Polypoidal choroidal vasculopathy in Caucasians. Graefes Arch Cin Exp Ophthalmol 238:752–759
Quaranta M, Maget-Faysse M, Coscas G (2002) Exudative idiopathic polypoidal choroidal vasculopathy and photodynamic therapy with verteporfin. Am J Ophthalmol 134:277–280
Spaide RF, Yannuzzi LA, Slakter JS, Sorenson J, Orlach DA (1995) Indocyanine green videoangiography of idiopathic polypoidal horoidal vasculopathy. Retina 15:100–110
Stern RM, Zakov N, Zegarra H, Gutman FA (1985) Multiple recurrent serosanguinous retinal pigment epithelial detachments in black women. Am J Ophthalmol 100:560–569
Bresller NM, Treatment of Age-related Macular Degeneration with Photodynamic Therapy (TAP) Study Group (2001) Photodynamic therapy of subfoveal choroidal neovascularisation in age-related macular degeneration with verteporfin. Two-year results of 2 randomized clinical trials–TAP report 2. Arch Ophthalmol 119:198–207
Uyama M, Wada M, Nagai Y, Matsubara T, Matsunaga H, Fukushima I, Takahashi K, Matsumura M (2002) Polypoidal choroidal vasculopathy: natural history. Am J Ophthalmol 133:639–648
Verteporfin in Photodynamic Therapy Study Group (2001) Verteporfin therapy of subfoveal choroidal neovascularisation in age-related macular degeneration: two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization—Verteporfin in Photodynamic Therapy Report 2. Am J Ophthalmol 131:541–560
Yannuzzi LA, Ciardella A, Spaide RF, Rabb M, Freund KB, Orlock DA (1997) The expanding clinical spectrum of idiopathic polypoidal choroidal vasculopathy. Arch Ophthalmol 115:478–485
Yannuzzi LA, Sorenson J, Spaide RF, Lipson B (1990) Idiopathic polypoidal choroidal vasculopathy (IPCV). Retina 10:1–8
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Silva, R.M., Figueira, J., Cachulo, M.L. et al. Polypoidal choroidal vasculopathy and photodynamic therapy with verteporfin. Graefe's Arch Clin Exp Ophthalmo 243, 973–979 (2005). https://doi.org/10.1007/s00417-005-1139-4
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DOI: https://doi.org/10.1007/s00417-005-1139-4