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Discrimination between normal and glaucomatous eyes using Stratus optical coherence tomography in Taiwan Chinese subjects

  • Clinical Investigation
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Abstract

Background

We differentiated between normal and glaucomatous eyes in the Taiwan Chinese population based solely on the quantitative assessment of summary data reports from Stratus optical coherence tomography (OCT) by comparing their area under the receiver operating characteristic (ROC) curve.

Methods

One randomly selected eye from each of the 62 patients with early glaucomatous damage (mean deviation −2.8 ± 1.8 dB) and from each of the 62 age- and sex-matched normal individuals were included in the study. Measurements of glaucoma variables (retinal nerve fiber layer thickness and optic nerve head analysis results) were obtained by Stratus OCT. Twenty-one OCT parameters were included in a linear discriminant analysis (LDA) using forward selection and backward elimination to determine the best combination of parameters for discriminating between glaucomatous and healthy eyes based on ROC curve area.

Results

The average RNFL thickness was the best individual parameter for differentiating between normal eyes and glaucomatous eyes (ROC curve area 0.793). The maximum area under the ROC curve of six input parameters (average RNFL thickness; 10, 11, and 12 o’clock segment thicknesses; cup area; and vertical integrated rim area) generated by the forward selection method was 0.881. Whereas the maximum area under the ROC curve of 15 input parameters (average RNFL thickness; 1, 3, 4, 6, 8–10, 12 o’clock segment thicknesses; vertical integrated rim area; horizontal integrated rim area; disc area; cup to disc area ratio; cup to disc horizontal ratio; and cup to disc vertical ratio) generated by backward elimination method was 0.929.

Conclusions

The performance of individual parameters obtained from Stratus OCT is fairly reliable for differentiating the early glaucomatous eyes from normal eyes. However, the discriminant power increases when LDA with forward selection and backward elimination methods is applied.

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Acknowledgements

The authors would like to thank the National Science Council of the Republic of China for financially supporting this research under contract no. NSC-93-2218-E-167-001.

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Authors and Affiliations

  1. Department of Ophthalmology, China Medical University Hospital, #2, Yuh-Der Road, Taichung City, 404, Taiwan

    Hsin-Yi Chen

  2. Department of Industrial Engineering and Management, National Chin-Yi Institute of Technology, Taiping City, Taichung County, 411, Taiwan

    Mei-Ling Huang

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Correspondence to Hsin-Yi Chen.

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Chen, HY., Huang, ML. Discrimination between normal and glaucomatous eyes using Stratus optical coherence tomography in Taiwan Chinese subjects. Graefe's Arch Clin Exp Ophthalmol 243, 894–902 (2005). https://doi.org/10.1007/s00417-005-1140-y

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  • DOI: https://doi.org/10.1007/s00417-005-1140-y

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