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Ocular perfusion pressure and retrobulbar haemodynamics in pseudoexfoliative glaucoma

  • Glaucoma
  • Published:
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Abstract

Background

Previous investigations have shown that vascular factors are involved in pseudoexfoliative glaucoma (XFG). The present study aims at comparing ocular perfusion pressure (OPP), diastolic ocular perfusion pressure (dOPP), and retrobulbar haemodynamics in pseudoexfoliative glaucoma and primary open-angle glaucoma (POAG).

Methods

Forty-seven XFGs, 41 POAGs, and 38 healthy controls were evaluated. OPP and dOPP were calculated. Peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistivity index (RI) were recorded in ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (SPCAs) by color Doppler imaging (CDI). Correlations between OPP and CDI parameters and between dOPP and CDI parameters were determined.

Results

OPP and dOPP were significantly lower in XFGs than in POAGs and controls (p < 0.001). CDI investigation revealed decreased EDV of OA, SPCAs, and CRA (p < 0.001) and increased RI of all the three considered vessels in XFGs compared with POAGs and controls (p < 0.001). A negative correlation between OPP and RI of OA and between dOPP and RI of OA was found in XFGs (p = 0.022 and p = 0.015 respectively).

Conclusions

Ocular perfusion pressure is decreased and retrobulbar haemodynamics are worse in pseudoexfoliative glaucoma patients than in primary open-angle glaucoma patients and healthy controls. An impaired ocular vascular regulation is suggested in pseudoexfoliative glaucoma.

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Authors and Affiliations

  1. Eye Clinic, University of Florence, viale Morgagni, 85-50134, Florence, Italy

    Fernando Galassi, Barbara Giambene & Ugo Menchini

Authors
  1. Fernando Galassi
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  2. Barbara Giambene
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  3. Ugo Menchini
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Corresponding author

Correspondence to Barbara Giambene.

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The authors have full control of all primary data, and they agree to allow Graefe’s Archive for Clinical and Experimental Ophthalmology to review their data upon request.

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Galassi, F., Giambene, B. & Menchini, U. Ocular perfusion pressure and retrobulbar haemodynamics in pseudoexfoliative glaucoma. Graefes Arch Clin Exp Ophthalmol 246, 411–416 (2008). https://doi.org/10.1007/s00417-007-0709-z

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  • DOI: https://doi.org/10.1007/s00417-007-0709-z

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