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Repeat renal biopsy in a girl with tubulointerstitial nephritis and uveitis syndrome

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Abstract.

A Japanese girl aged 8 years who presented with a 2-month history of uveitis subsequently developed tubulointerstitial nephritis. A percutaneous renal biopsy revealed massive interstitial mononuclear cell infiltrates consisting of CD4-positive T cells. Despite administration of topical corticosteroids, the ocular symptoms persisted. Systemic corticosteroid therapy dramatically reduced the ocular symptoms and urinary β2-microglobulin (β 2MG) concentration. However, reducing the prednisolone dosage induced recurrence of uveitis associated with increased levels of urinary β 2MG. The CD4-positive T cell infiltration persisted in the second renal biopsy performed 6 months after the first renal biopsy. These observations suggest that the interstitial cell infiltration persists for a relatively long time in a proportion of patients with tubulointerstitial nephritis and uveitis syndrome (TINU). Although the renal outcome of TINU has been reported to be favorable, prolonged interstitial cell infiltration may affect long-term renal outcome. Selected patients with TINU should be followed with close observation.

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Received: 7 February 2001 / Revised: 8 June 2001 / Accepted: 27 June 2001

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Tanaka, H., Suzuki, K., Nakahata, T. et al. Repeat renal biopsy in a girl with tubulointerstitial nephritis and uveitis syndrome. Pediatr Nephrol 16, 885–887 (2001). https://doi.org/10.1007/s004670100697

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  • DOI: https://doi.org/10.1007/s004670100697

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