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Cycloplegic Effect of 0.5%Tropicamide and 0.5%Phenylephrine Mixed Eye Drops: Objective Assessment in Japanese Schoolchildren with Myopia

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Abstract

Purpose

To evaluate the cycloplegic effect of mixed eye drops containing 0.5% tropicamide and 0.5% phenylephrine in myopic children, and to determine whether their efficacy was associated with their clinical characteristics.

Methods

Eighty-one myopic children (age, mean ± SD, 11.0 ± 1.5 years; mean spherical equivalent refractive error, −4.27 ± 1.41 D; range, −1.57 to −8.66 D) were recruited. One drop of Mydrin-P was administered to each eye twice, with an interval of 5 min between. Twenty-five minutes after the second drop, accommodative responses were measured with an open-view autorefractometer, while the subject was encouraged to accommodate by binocularly looking at a Maltese cross located at a distance of 33 cm. The difference between the refractive reading and that obtained with a Maltese cross at 500 cm was regarded as residual accommodation (RA). The repeatability of this measurement was also evaluated.

Results

The mean RA was 0.21 ± 0.29 D (range, −0.31 to 0.99 D). There was no association in RA between the right and left eyes, between RA and age, or between RA and sex, but RA was weakly correlated with refractive error (r = 0.274, P = 0.019). The intersubject difference found in RA can be explained mostly by the extent of repeatability (±0.71 D).

Conclusion

The insignificant magnitude of RA indicated that the mixed eye drop is an acceptable and useful cycloplegic agent in Japanese schoolchildren with a wide range of myopic refractive errors. Jpn J Ophthalmol 2007;51:111–115 © Japanese Ophthalmological Society 2007

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Authors and Affiliations

  1. Department of Ophthalmology, Okayama University, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan

    Ichiro Hamasaki, Satoshi Hasebe, Shuhei Kimura, Manabu Miyata & Hiroshi Ohtsuki

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  1. Ichiro Hamasaki
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  2. Satoshi Hasebe
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  3. Shuhei Kimura
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  4. Manabu Miyata
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  5. Hiroshi Ohtsuki
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Correspondence to Satoshi Hasebe.

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Hamasaki, I., Hasebe, S., Kimura, S. et al. Cycloplegic Effect of 0.5%Tropicamide and 0.5%Phenylephrine Mixed Eye Drops: Objective Assessment in Japanese Schoolchildren with Myopia. Jpn J Ophthalmol 51, 111–115 (2007). https://doi.org/10.1007/s10384-006-0400-7

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  • DOI: https://doi.org/10.1007/s10384-006-0400-7

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