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Microbial keratitis in West Anatolia, Turkey: a retrospective review

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Abstract

Purpose

To analyze the clinical and microbiological characteristics of microbial keratitis in West Anatolia, Turkey during a 16-year period.

Methods

This is a retrospective study in which medical records were reviewed for all eyes with clinically diagnosed microbial keratitis presenting at the Izmir Ataturk Training and Research Hospital from January 1990 to December 2005. Risk factors, microbial isolations and clinical features were analyzed.

Results

Microbial keratitis was diagnosed for 620 eyes in 620 patients (250 women and 370 men; mean age: 54.13 years ± 20.06). Pathogens from cultures were identified for 225 eyes (36.2%) and included Gram-negative (8.9%) and Gram-positive micro-organisms (68.8%) and fungi (22.3%). Staphylococcus epidermidis was the most commonly isolated micro-organism (26.6%), followed by S. aureus (24.4%), Streptococci pneumoniae (15.5%), fungi (22.3%), Pseudomonas species (6.6%), Enterobacter (2.2%) and Corynebacterium (2.2%). Ocular trauma was the most common predisposing factor (26.6%). Mean duration from onset of symptoms to diagnosis was 11.68 ± 11.29 days.

Conclusion

Staphylococci are the most commonly isolated microbial agents in cases of infectious keratitis in West Anatolia, Turkey. These findings will provide valuable background information and facilitate successful treatment in this region, and they will be useful as reference data for the particular population in this region as a basis for empirical antibiotic therapy.

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References

  1. Upadhyay MP, Karmacharya PC, Koirala S, Tuladhar NR, Bryan LE, Smolin G et al (1991) Epidemiologic characteristics, predisposing factors, and aetiologic diagnosis of corneal ulceration in Nepal. Am J Ophthalmol 111:92–99

    PubMed  CAS  Google Scholar 

  2. Gonzales CA, Srinivasan M, Whitcher JP, Smolin G (1996) Incidence of corneal ulceration in Madurai District, south India. Ophthalmic Epidemiol 3:159–166

    PubMed  CAS  Google Scholar 

  3. Whitcher JP, Srinivasan M, Upadhayay MP (2001) Corneal blindness: a global perspective. Bull World Health Organ 79:214–221

    PubMed  CAS  Google Scholar 

  4. Whal JC, Katz HR, Abrams DA (1991) Infectious keratitis in Baltimore. Ann Ophthalmol 23:234–237

    Google Scholar 

  5. Goldstein MH, Kowalski RP, Gordon YJ (1999) Emerging fluoroquinolone resistance in bacterial keratitis. Ophthalmology 106:1313–1318

    PubMed  CAS  Google Scholar 

  6. Ormerod LD, Hertzmark E, Gomez DS et al. (1987) Epidemiology of microbial keratitis in southern California: a multivariate analysis. Ophthalmology 94:1322–1333

    PubMed  CAS  Google Scholar 

  7. Srinivasan M, Gonzales CA, George C, Cevallos V, Mascarenhas JM, Asokan B et al. (1997) Epidemiology and aetiological diagnosis of corneal ulceration in Madurai, south India. Br J Ophthalmol 8:965–971

    Google Scholar 

  8. Bharathi MJ, Ramakrishnan R, Vasu S, Meenakshi R, Palaniappan R (2003) Epidemiological characteristics and laboratory diagnosis of fungal keratitis: a three-year study. Indian J Ophthalmol 51:315–321

    PubMed  Google Scholar 

  9. Jones DB (1981) Decision-making in the management of microbial keratitis. Ophthalmology 88:814–820

    PubMed  CAS  Google Scholar 

  10. Baum JL (1979) Initial therapy of suspected microbial corneal ulcers. I. Broad antibiotic therapy based on prevalence of organisms. Surv Ophthalmol 24:97–105

    Article  PubMed  CAS  Google Scholar 

  11. Blanton CL, Rapuano CJ, Cohen EJ, Laibson PR (1996) Initial treatment of microbial keratitis. CLAO J 22:136–140

    PubMed  CAS  Google Scholar 

  12. Asbell P, Stenson S (1982) Ulcerative keratitis: survey of 30 years’ laboratory experience. Arch Ophthalmol 100:77–80

    PubMed  CAS  Google Scholar 

  13. Maske R, Hill JC, Oliver SP (1986) Management of bacterial corneal ulcers. Br J Ophthalmol 70:199–201

    PubMed  CAS  Google Scholar 

  14. Mahajan VM (1983) Acute bacterial infections of the eye: their etiology and treatment. Br J Ophthalmol 67:191–194

    PubMed  CAS  Google Scholar 

  15. Bourcier T, Thomas F, Borderie V et al (2003) Bacterial keratitis: predisposing factors, clinical and microbiological review of 300 cases. Br J Ophthalmol 87:834–838

    Article  PubMed  CAS  Google Scholar 

  16. Cheng KH, Leung SL, Hoekman HW et al (1999) Incidence of contact-lens-associated microbial keratitis and its related morbidity. Lancet 354:181–185

    Article  PubMed  CAS  Google Scholar 

  17. Jones DB (1979) Initial therapy of suspected microbial corneal ulcers. II. Specific antibiotic therapy based on corneal smears. Surv Ophthalmol 24:105–116

    Article  Google Scholar 

  18. Katz NN, Wadud SA, Ayazuddin M (1983) Corneal ulcer disease in Bangladesh. Ann Ophthalmol 15:834–836

    PubMed  CAS  Google Scholar 

  19. Carmichael TR, Wolpert M, Koornhof HJ (1985) Corneal ulceration at an urban African hospital. Br J Ophthalmol 69:920–926

    PubMed  CAS  Google Scholar 

  20. Samarrai AR, Sunba MS (1989) Bacterial corneal ulcers among Arabs in Kuwait. Ophthalmic Res 21:278–284

    Article  Google Scholar 

  21. Despande SD, Koppikar GV (1999) A study of mycotic keratitis in Mumbai. Indian J Pathol Microbiol 42:81–87

    Google Scholar 

  22. Garg P, Gopinathan U, Choudhary K, Rao GN (2000) Keratomycosis: clinical and microbiological experience with dematiaceous fungus. Ophthalmology 107:574–580

    Article  PubMed  CAS  Google Scholar 

  23. Leck AK, Thomas PA, Hagan M, Kaliamurthy J, Ackuaku E, John M et al (2002) Aetiology of suppurative corneal ulcers in Ghana and south India, and epidemiology of fungal keratitis. Br J Ophthalmol 86:1211–1215

    Article  PubMed  CAS  Google Scholar 

  24. Dunlop AA, Wright ED, Howlader SA, Nazrul I, Hussain R, McCellan K et al (1994) Suppurative corneal ulceration in Bangladesh: a study of 142 cases examining the microbial diagnosis, clinical and epidemiological features of bacterial and fungal keratitis. Aust N Z Ophthalmol 22:105–110

    CAS  Google Scholar 

  25. Liesegang TJ, Forstor RK (1980) Spectrum of microbial keratitis in south Florida. Am J Ophthalmol 90:38–47

    PubMed  CAS  Google Scholar 

  26. Mino de Kasper H, Zoulek G, Paredes ME, Alborno R, Medina D, Centurian de Morinigo M et al. (1991) Mycotic keratitis in Paraguay. Mycoses 34:251–254

    Article  Google Scholar 

  27. Gugnani HC, Talwar RS, Njoku-Obi AN, Kodilinye HC (1976) Mycotic keratitis in Nigeria. A study of 21 cases. Br J Ophthalmol 60:607–613

    PubMed  CAS  Google Scholar 

  28. Mselle J (1999) Fungal keratitis as an indicator of HIV infection in Africa. Trop Doct 29:133–135

    PubMed  CAS  Google Scholar 

  29. Wong TY, Fong KS, Tan DTH (1997) Clinical and microbiological spectrum of fungal keratitis in Singapore: a 5-year retrospective study. Int Ophthalmol 21:127–130

    Article  PubMed  CAS  Google Scholar 

  30. Wong T, Ormonde S, Gamble G, McGhee CN (2003) Severe infective keratitis leading to hospital admission in New Zealand. Br J Ophthalmol 87:1103–1108

    Article  PubMed  CAS  Google Scholar 

  31. Keay L, Edwards K, Naduvilath T, Taylor HR, Snison GR, Forde K et al (2006) Microbial keratitis predisposing factors and morbidity. Ophthalmology 113:109–116

    Article  PubMed  Google Scholar 

  32. Williams G, Billson F, Husain R, Howlader SA, Islam N, McCellan K (1987) Microbiological diagnosis of suppurative keratitis in Bangladesh. Br J Ophthalmol 71:315–321

    PubMed  CAS  Google Scholar 

  33. Thylefors B (1992) Epidemiological patterns of ocular trauma. Aust N Z J Ophthalmol 20:95–98

    CAS  Google Scholar 

  34. Hagan M, Wright E, Newman M, Dolin P, Johnson G (1995) Causes of suppurative keratitis in Ghana. Br J Ophthalmol 79:1024–1028

    PubMed  CAS  Google Scholar 

  35. Jeng BH, McLeod SD (2003) Microbial keratitis (Editorial). Br J Ophthalmol 87:805–806

    Article  PubMed  CAS  Google Scholar 

  36. Sanchez-Thorin JC (1998) The cornea in diabetes mellitus. Int Ophthalmol Clin 38:19–36

    Article  PubMed  CAS  Google Scholar 

  37. Saini JS, Khandalavla B (1995) Corneal epithelial fragility in diabetes mellitus. Can J Ophthalmol 30:142–146

    PubMed  CAS  Google Scholar 

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Correspondence to Safiye Yilmaz.

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Yilmaz, S., Ozturk, I. & Maden, A. Microbial keratitis in West Anatolia, Turkey: a retrospective review. Int Ophthalmol 27, 261–268 (2007). https://doi.org/10.1007/s10792-007-9069-2

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  • DOI: https://doi.org/10.1007/s10792-007-9069-2

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