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Hydroxyapatite scaffolds for bone tissue engineering made by 3D printing

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Abstract

Nowadays, there is a significant need for synthetic bone replacement materials used in bone tissue engineering (BTE). Rapid prototyping and especially 3D printing is a suitable technique to create custom implants based on medical data sets. 3D printing allows to fabricate scaffolds based on Hydroxyapatite with complex internal structures and high resolution. To determine the in vitro behaviour of cells cultivated on the scaffolds, we designed a special test-part. MC3T3-E1 cells were seeded on the scaffolds and cultivated under static and dynamic setups. Histological evaluation was carried out to characterise the cell ingrowth. In summary, the dynamic cultivation method lead to a stronger population compared to the static cultivation method. The cells proliferated deep into the structure forming close contact to Hydroxyapatite granules.

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Authors and Affiliations

  1. Research Center Caesar, Ludwig-Erhard-Allee 2, 53175, Bonn

    Barbara Leukers, Stephan H. Irsen, Carsten Tille & Hermann Seitz

  2. Experimental Surgery and Regenerative Medicine, Department of Surgery—Downtown, University of Munich, Nussbaumstrasse 20, 80336, München

    Hülya Gülkan & Matthias Schieker

  3. AO Research Institute, Clavadelerstrasse, 7270, Davos, Switzerland

    Stefan Milz

Authors
  1. Barbara Leukers
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  2. Hülya Gülkan
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  3. Stephan H. Irsen
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  4. Stefan Milz
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  5. Carsten Tille
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  6. Matthias Schieker
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  7. Hermann Seitz
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Leukers, B., Gülkan, H., Irsen, S.H. et al. Hydroxyapatite scaffolds for bone tissue engineering made by 3D printing. J Mater Sci: Mater Med 16, 1121–1124 (2005). https://doi.org/10.1007/s10856-005-4716-5

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  • DOI: https://doi.org/10.1007/s10856-005-4716-5

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