Original articleRegulation of proliferation and differentiation of respiratory tract epithelial cells by TGFβ
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2009, American Journal of PathologyCitation Excerpt :Among the many factors that have been identified and regulate positively or negatively the growth and differentiation of airway epithelial cells by autocrine or paracrine mechanisms, transforming growth factor β (TGF-β), a major cytokine involved in driving squamous metaplasia, is of particular interest. Jetten et al.38 and Masui et al.64 have indeed shown that TGF-β exposure or overexpression in airway epithelial cells induces terminal cell division and favors the expression of a squamous phenotype. Similarly in the present study, αBTX-induced hyperproliferation is followed by a period in which cells stop proliferating and undergo squamous differentiation, suggesting that these changes in the differentiation pathway, when α7 nAChR is absent or inactivated, may be related to TGF-β overexpression.
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