Angiotensin I converting enzyme (kininase II) in ocular tissues

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Abstract

The retina, choroid, ciliary body and the microvessels isolated from retina and ciliary body of human, bovine, pig and/or rabbit eyes contain a high activity of angiotensin I converting enzyme. The activity of the enzyme was determined by bioassay of bradykinin on the isolated rat uterus and by u.v. spectrophotometric assay with hippuryl-glycil-glycine as a substrate. The highest activity of the enzyme was found in blood vessels isolated of the pig retina. The presence of the enzyme in the eye structures mentioned suggest a role in the metabolism of vasoactive peptides, angiotensin II generation and bradykinin inactivation, that are possibly involved in local regulation of blood flow.

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