Analysis of rat lens 45Ca2+ fluxes: Evidence for Na+Ca2+ exchange
References (32)
- et al.
Effect of 8-methoxypsoralen on rat lens cations, membrane potential and protein levels
Exp. Eye Res.
(1984) - et al.
Ion analysis of human cataractous lenses
Exp. Eye Res.
(1975) In vivo and in vitro observations on permeability and diffusion pathways of tracers in rat and frog lenses
Exp. Eye Res.
(1987)- et al.
Calcium-induced opacification and loss of protein in the organ-cultured bovine lens
Exp. Eye Res.
(1986) - et al.
The localisation of transport properties in the frog lens
Biophys. J.
(1985) - et al.
Calcium metabolism in the rabbit lens
Exp. Eye Res.
(1983) - et al.
The extracellular space of the lens
Exp. Eye Res.
(1965) - et al.
Calcium-induced cleavage and breakdown of spectrin in the rat lens
Biochem. Biophys. Res. Commun.
(1989) - et al.
Sodium-calcium exchange and smooth muscle function in non-vascular smooth muscles
- et al.
The effect of sodium concentration on calcium movements in giant axon of Loligo forbesi
J. Physiol.
(1967)
The influence of extracellular calcium binding on the calcium efflux from squid axon
J. Physiol.
Efflux of chloride from the rat lens: influence of membrane potential and intracellular acidification
Q. J. Exp. Physiol.
Membrane electrical properties of vesicular NaCa exchange inhibitors in single atrial myocytes
Circulation Res.
Studies on Na-K-ATPase. Correlation of enzyme activity with cation flux in six tissues
Arch. Biochem. Biophys.
Ca-ATPase activity in the rabbit and bovine lens
Invest. Ophthalmol. Vis. Sci.
Contribution of isotope flux studies to understanding the mechanism of the β-cell membrane
Cited by (28)
Calcium entry via connexin hemichannels in lens epithelium
2015, Experimental Eye ResearchCitation Excerpt :Differences between calcium regulation in lens epithelium and fiber cells are likely because the baseline cytoplasmic calcium in the epithelium (∼100 nM) is lower than that in the fibers where the concentration is ∼300 nM in the outer fibers and ∼700 nM in the inner fibers (Gao et al., 2004). NCX is thought to play a significant role in lens calcium regulation (Tomlinson et al., 1991) and binding also may be important (Dahm and Prescott, 2003). Failure of lens calcium homeostasis is associated with loss of transparency (Lee et al., 2008).
Inhibition of diabetic-cataract by vitamin K1 involves modulation of hyperglycemia-induced alterations to lens calcium homeostasis
2014, Experimental Eye ResearchCitation Excerpt :One important consequence of increase in lens Ca2+ is the activation of calpain that are Ca2+-dependent proteinases (David and Shearer, 1984). This loss of lens Ca2+ homeostasis might be an important mediator for cataract onset (Shearer and David, 1983; David and Shearer, 1984) and studies have indeed identified the importance of lens membrane ATPases in regulating endogenous Ca2+ (Bergad and Rathbun, 1986; Tomlinson et al., 1991; Wang et al., 1992). Apart from surgical removal of cataractous lens, there are no therapeutic strategies available in case of diabetic cataract.
Magnesium deficiency: Does it have a role to play in cataractogenesis?
2012, Experimental Eye ResearchCurcumin prevents free radical-mediated cataractogenesis through modulations in lens calcium
2010, Free Radical Biology and MedicineThe mechanisms of calcium homeostasis and signalling in the lens
2009, Experimental Eye ResearchCitation Excerpt :The presence of a Na+/Ca2+ exchange mechanism in the lens was first indicated in experiments using membrane vesicles isolated from bovine lens fibre cells (Galvan and Louis, 1988). Na+/Ca2+ exchange activity was investigated in greater detail by Tomlinson et al. (1991) who demonstrated that in the intact rat lens, 55% of Ca2+ efflux from the lens was dependent on extracellular Na+. Activity has since been confirmed in human lens as well as in other species (Ye and Zadunaisky, 1992; Duncan et al., 1993; Okafor et al., 2003).
The influence of sodium-calcium exchange inhibitors on rabbit lens ion balance and transparency
2006, Experimental Eye ResearchCitation Excerpt :Under low sodium conditions that are likely to inhibit NCX-mediated calcium export, lenses became severely opaque. This fits with a report by Tomlinson and coworkers (Tomlinson et al., 1991) who observed opacification in rat lenses incubated in sodium-free conditions. Transparency in the rabbit lens was lost at both anterior and posterior.