The choriocapillaris in spontaneously diabetic rats
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Choriocapillaris: Fundamentals and advancements
2022, Progress in Retinal and Eye ResearchCitation Excerpt :It appears that choriocapillaris atrophy is secondary in geographic atrophy but primary in wet AMD (McLeod et al., 2009). In diabetes, there is an increased extracellular matrix material (Caldwell and Fitzgerald, 1991) (Fig. 5), and upregulation of ICAM-1 and P-selectin expression (McLeod et al., 1995). There was no difference in the pericyte disposition in the choriocapillaris in normal and diabetic rats (Tilton et al., 1986).
Choroidal and retinal structural, cellular and vascular changes in a rat model of Type 2 diabetes
2020, Biomedicine and PharmacotherapyCitation Excerpt :Interestingly, this disposition is shared by stromal Iba1+ cells in the same location (S1−6 Videos). Reduction of the vascular component of the diabetic CC reported in OCTA studies did not separate permanent degenerative from transient and reversible changes, mirroring increased CC remodeling in diabetes reported in postmortem studies in humans and in rats [11,49,50,56]. Increased remodeling of the CC, probably mediated by abluminal pericytes contacting the endothelium as peg-in-socket or tongue-in-socket processes, may be an adaptation to the pore kinetics, water load, ionic and pH alterations, VEGF levels and the presence of inflammatory mediators and cells in the diabetic choroid [55,57].
Erythrocyte flow in choriocapillaris of normal and diabetic rats
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2008, MicrocirculationEffects of curcumin on restoration and improvement of microvasculature characteristic in diabetic rat’s choroid of eye
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