Elsevier

Survey of Ophthalmology

Volume 22, Issue 2, September–October 1977, Pages 69-87
Survey of Ophthalmology

Review
Tear physiology and dry eyes

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Abstract

The conditions of tear film formation and stability are governed by the surface chemical characteristics of the tear film system and by the proper functioning of the lacrimal apparatus. The tear film has to remain continuous between blinks in order to fulfill its function. The presence of an abnormal tear film results in dry eye states that can be detrimental to vision. The diagnostic tests presently available are limited mainly to approximately determining tear secretion rate and estimating epithelial damage by staining techniques. The only test that directly measures tear film stability is one which determines tear film breakup time. The treatment modalities depend on the type of irregularity causing the dry eye state and range from the application of artificial tear substitutes or the obstruction of the puncta to surgical alterations of the lacrimal system.

References (119)

  • F.J. Holly

    Surface chemistry of tear film component analogs

    J Coll Interface Sci

    (1974)
  • L.T. Jones

    The lacrimal secretory system and its treatment

    Am J Ophthalmol

    (1966)
  • J.H. Krachmer et al.

    Corneal thinning and perforation in Sjögren's syndrome

    Am J Ophthalmol

    (1974)
  • M.L. Linn et al.

    Rate of lacrimal excretion of ophthalmic vehicles

    Am J Ophthalmol

    (1968)
  • J.E. McDonald et al.

    Meniscus-induced thinning of tear films

    Am J Ophthalmol

    (1971)
  • S Mishima et al.

    The oily layer of the tear film and evaporation from the corneal surface

    Exp Eye Res

    (1961)
  • Abelson M, Holly FJ: Inferior punctate keratopathy: A tentative mechanism. Am J Ophthalmol (in...
  • M.J. Absalon et al.

    Acetylcysteine in kerato-conjunctivitis sicca

    Br J Ophthalmol

    (1968)
  • D. Alarcon-Segovia et al.

    Sjögren syndrome in systemic lupus erythematosus

    Ann Intern Med

    (1974)
  • M.G. Alper

    The anesthetic eye: An investigation of changes in the anterior ocular segment of the monkey caused by interrupting the trigeminal nerve at various levels along its course

    Trans Am Ophthalmol Soc

    (1975)
  • G.W.H.M. van Alphen

    Acetylcholine synthesis in corneal epithelium

    Arch Ophthalmol

    (1957)
  • J.D. Andrade

    Interfacial phenomena and biomaterials

    Med Instru

    (1973)
  • J.S. Andrews

    The meibomian secretion

  • R Asofsky et al.

    Sjögren's syndrome — newer aspects of research, diagnosis and therapy

    Ann Int Med

    (1971)
  • R.C. Bach et al.

    Ocular retention of artificial tear solutions. Comparison of HPMC and PVA vehicles using an argyrol marker

    Ann Ophthalmol

    (1972)
  • I Beitch

    The induction of keratinization of the corneal epithelium. A comparison of the “dry” and vitamin A-deficient eyes

    Invest Ophthalmol

    (1970)
  • J.E. Bennett

    The management of total xerophthalmia

    Arch Ophthalmol

    (1969)
  • J.E. Bennett et al.

    A surgical approach to total xerophthalmia. Transplantation of the parotid duct to the inferior cul-de-sac

    Arch Ophthalmol

    (1957)
  • J.E. Bennett et al.

    Surgical treatment of total xerophthalmia. Transplantation of the parotid duct to the inferior cul-de-sac with report of a case

    Arch Ophthalmol

    (1957)
  • R.E. Berger et al.

    A surface tension gradient mechanism for driving the precorneal tear film after blinking

    J Biomechanics

    (1974)
  • O.P. van Bijsterveld

    Diagnostic tests in the sicca syndrome

    Arch Ophthalmol

    (1969)
  • O.P. van Bijsterfeld

    Standardization of the lysozyme test for a commercially available medium

    Arch Ophthalmol

    (1974)
  • O.P. van Bijsterfeld

    Lipolytic activity of Staph. aureus from different sources

    J Med Microbiol

    (1976)
  • G Bologenini et al.

    Lymphoproliferative diseases and paraproteinemias in Sjögren syndrome

    Schweig Med Wochenschr

    (1975)
  • M Bonnet

    Traitément du syndrome de Gouerot-Sjögren

    Ann Ocul (Paris)

    (1970)
  • S.I. Brown et al.

    The oils of the meibomian glands: Physical and surface characteristics

    Arch Ophthalmol

    (1969)
  • Cardona H: The history and status of keratoprosthesis. In King JH, Lemp MA (eds): The Cornea — A Clinical Text. Boston,...
  • D.M. Chisholm et al.

    Labial salivary gland biopsy in Sjögren's disease

    J Clin Pathol

    (1968)
  • J.R. Cook et al.

    Lacrimal sarcoidosis treated with corticosteroids

    Arch Ophthalmol

    (1972)
  • G DeCaro et al.

    The treatment of Sjögren's syndrome with psysalaemin

    Ophthalmologica

    (1969)
  • S Duke-Elder
  • S Duke-Elder
  • N Ehlers

    The precorneal tear film

    Acta Ophthalmol (Copenhagen)

    (1965)
  • N Ehlers et al.

    Quantitative amounts of conjunctival mucous secretion and tears

    Acta Ophthalmol

    (1972)
  • A Fleming

    On remarkable bacteriolytic element found in tissue and secretions

  • J.M. Freeman

    Puctum plug: Evaluation of a new treatment for dry eye

    Trans Am Acad Ophthalmol Otolaryngol

    (1975)
  • V.J. Gaule

    Effect of trigeminal nerve on the cornea

    Z Physiologie

    (1891–1892)
  • M Gnädinger

    Die acetylcholin-Spaltungsfähigkeit des Epithels der Kaninchenhornhaut

    Ophthalmologica

    (1967)
  • F.J. Grosse-Ruyken

    Über line Behandlungsmöglichkeit der Conjunctivitis sicca und des Sjögren mit einem Sekretolytikum

    Klin Monatsbl Augenheilkd

    (1973)
  • P.P. Gudas et al.

    Corneal perforation in Sjögren's syndrome

    Arch Ophthalmol

    (1973)
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