Elsevier

Survey of Ophthalmology

Volume 24, Issue 2, September–October 1979, Pages 57-88
Survey of Ophthalmology

Review
Adverse external ocular effects of topical ophthalmic medications☆

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Abstract

Medical and pharmacologic research of recent years has led to the development of many potent and efficacious topical ophthalmic medications. Unfortunately, many of these drugs are potentially toxic or allergenic, and their adverse effects have themselves become important external ocular diseases. This paper presents a classification of these adverse effects and provides a review of their etiology, pathogenesis, histopathology, diagnosis, and management. It is hoped that this information will be helpful to ophthalmologists in their efforts to anticipate, prevent, recognize, and treat drug-induced ocular problems and that it will serve to emphasize the importance of avoiding the ill-considered use of medications.

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    ☆

    This work was supported in part by a grant from Research to Prevent Blindness, Inc., New York.

    This paper was presented in part at the Third Annual Proctor Fellows Meeting, Francis I. Proctor Foundation for Research in Ophthalmology, University of California, San Francisco, June 16, 1977; at the University of Illinois Eye and Ear Infirmary, Chicago, September 1, 1977; and at a meeting of the Columbus Ophthalmologic and Otolaryngologic Society, Columbus, Ohio, October 2, 1978.

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