Elsevier

Survey of Ophthalmology

Volume 28, Issue 6, May–June 1984, Pages 621-642
Survey of Ophthalmology

Review
Aniridia. A review

https://doi.org/10.1016/0039-6257(84)90184-XGet rights and content

Abstract

Aniridia occurs as a phenotypically heterogeneous condition which may be inherited as an autosomal dominant disorder or as part of several systemic syndromes. It has been linked with the loci of chromosomes 1 and 2 and associated with the deletion of the p-13 band of chromosome 11. Aniridia may occur in a highly penetrant form in association with other ocular abnormalities with poor vision or in a more variable form with good vision. The recognition of a child with sporadic aniridia should alert physicians to the increased risk of development of Wilms' tumor.

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    Supported in part by a grant from Fight For Sight, Inc., of New York to the Fight For Sight Children's Eye Center, Wills Eye Hospital, Philadelphia, Pennsylvania.

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