Elsevier

Human Pathology

Volume 25, Issue 9, September 1994, Pages 849-856
Human Pathology

Progress in pathology
Adhesion molecules: Novel molecular tools in tumor pathology

https://doi.org/10.1016/0046-8177(94)90002-7Get rights and content

Abstract

Cell adhesion is a key process, elementary in the establishment of tissue architecture and differentiation. In neoplasia, in which there is a disruption of tissue architecture and a derangement in differentiation, it has been postulated that changes in cell-cell and cell-matrix interactions account for the ability of cancer cells to transgress normal tissue boundaries and disperse to distant sites. Complex and coordinated reductions and increases in adhesion have been proposed to be necessary for tumor invasion and metastasis. This hypothesis has fueled the interest of cancer research teams to evaluate the expression of various adhesion molecules in a wide range of human malignancies in the hope of pinpointing some of the cell adhesion alterations underlying tumor behavior. To date, a multitude of transmembrane glycoproteins, including cell-cell adhesion molecules (CAMs) and cell-matrix or substratum adhesion molecules (SAMs), have been identified; their structure, molecular genetics, and biochemistry have been elucidated, and we are beginning to understand their normal function. A few of these, on the basis of current evidence, seem to be promising candidate molecules for a role in neoplasia. This article aims to summarize recent developments in this field of adhesion research as well as the clinical applications in diagnostic pathology arising from it. First, by way of introduction, a summary of the biochemical and functional characterization of each family of adhesion receptors will be presented, followed by a presentation of the experimental data implicating them in the control of invasion, metastasis, and differentiation.

References (100)

  • P Gold et al.

    Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques

    J Exp Med

    (1965)
  • Y Matsushita et al.

    Sialydomeric Lewis-x antigen expressed on mucin-like glycoproteins in colorectal cancer metastases

    Lab Invest

    (1990)
  • I Stamenkovic et al.

    A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family

    Cell

    (1989)
  • I Stamenkovic et al.

    The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate bearing cells

    EMBO J

    (1991)
  • Y Matsumara et al.

    Significance of CD44 gene products for cancer diagnosis and disease evaluation

    Lancet

    (1992)
  • D Tarin et al.

    Deranged CD44 gene activity in malignancy

    J Pathol

    (1993)
  • MJ Elices et al.

    The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others

  • LR Languino et al.

    Endothelial cells use Ī±2Ī²1 integrin as a laminin receptor

    J Cell Biol

    (1989)
  • E Ruoslahti et al.

    New perspectives in cell adhesion: RGD and integrins

    Science

    (1987)
  • M Pignatelli et al.

    Genetics and biochemistry of collagen-binding triggered glandular differentiation in a human colon carcinoma cell line

  • SM Albelda

    Biology of disease: Role of integrins and other cell adhesion molecules in tumor progression and metastasis

    Lab Invest

    (1993)
    SM Albelda

    Biology of disease: Role of integrins and other cell adhesion molecules in tumor progression and metastasis

    Lab Invest

    (1993)
  • M Pignatelli et al.

    Adhesion molecules in neoplasia: An overview

  • LC Plantefaber et al.

    Changes in integrin receptors on oncogenically transformed cells

    Cell

    (1989)
  • MM Zutter et al.

    Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast

    Am J Pathol

    (1990)
  • MM Zutter et al.

    Altered integrin expression in adenocarcinoma of the breast

    Am J Pathol

    (1993)
  • GK Koukoulis et al.

    Immunohistochemical localization of integrins on the normal, hyperplastic and neoplastic breast

    Am J Pathol

    (1991)
  • M Pignatelli et al.

    Low expression of Ī²1, Ī±2 and Ī±3 subunits of VLA integrins in malignant mammary tumors

    J Pathol

    (1991)
  • M Pignatelli et al.

    Integrins and their accessory adhesion molecules in mammary carcinomaā€”Loss of polarisation in poorly differentiated tumors

    Hum Pathol

    (1992)
  • K Koretz et al.

    Expression of VLA-Ī±2, VLA-Ī±6, and VLA-Ī²1 chains on normal mucosa and adenomas of the colon and in colon carcinomas and their liver metastases

    Am J Pathol

    (1991)
  • A Stallmach et al.

    Diminished expression of integrin adhesion molecules on human colonic epithelial cells during the benign to malignant tumor transformation

    Gut

    (1992)
  • AK Nigam et al.

    Loss of cell-cell and cell-matrix adhesion molecules in colorectal cancer

    Br J Cancer

    (1993)
  • GK Koukoulis et al.

    Immunolocalization of integrins in the normal and neoplastic colonic epithelium

    Virchows Arch B Cell Pathol

    (1993)
  • H Bonkhoff et al.

    Differential expression of Ī±6 and Ī±2 very late antigen integrins in the normal, hyperplastic, and neoplastic prostate

    Hum Pathol

    (1993)
  • PA Hall et al.

    Characterization of integrin chains in normal and neoplastic human pancreas

    J Pathol

    (1991)
  • M Korhonen et al.

    Integrin distribution in renal cell carcinomas of various grades of malignancy

    Am J Pathol

    (1992)
  • J Peltonen et al.

    Localization of integrin receptors for fibronectin, collagen and laminin in human skin

    J Clin Invest

    (1989)
  • GWH Stamp et al.

    Distribution of Ī²1, Ī±1, Ī±2 and Ī±3 integrin chains in basal cell carcinomas

    J Pathol

    (1991)
  • JF Marshall et al.

    Integrin expression in human melanoma cell lines: Heterogeneity of vitronectin receptor composition and function

    Int J Cancer

    (1991)
  • SM Albelda et al.

    Integrin distribution in malignant melanoma: Association of the Ī²3 subunit with tumor progression

    Cancer Res

    (1990)
  • B Felding-Habermann et al.

    Involvement of integrin Ī±v gene expression in human melanoma tumorigenicity

    J Clin Invest

    (1992)
  • PG Natali et al.

    Tumor progression in malignant melanoma is associated with changes in Ī±6Ī²1 laminin receptor

    Int J Cancer

    (1991)
  • BMC Chan et al.

    In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells

    Science

    (1991)
  • E Carico et al.

    Integrin Ī²4 expression in the neoplastic progression of cervical epithelium

    Gynecol Oncol

    (1993)
  • M Pignatelli et al.

    Morphoregulatory activities of E-cadherin and beta-1 integrins in colorectal tumor cells

    Br J Cancer

    (1992)
  • D Liu et al.

    Transforming growth factor alpha can act as morphogen and/or mitogen in a colorectal carcinoma cell line

    Int J Cancer

    (1994)
  • P Tapley et al.

    Integrins isolated from rous sarcoma virusā€”Transformed chicken embryo fibroblasts

    Oncogene

    (1989)
  • OK Oz et al.

    Reduced cell adhesion to fibronectin and laminin is associated with altered glycosylation of Ī²1 integrins in a weakly metastatic glycosylation mutant

    Int J Cancer

    (1989)
  • JC Adams et al.

    Fibronectin inhibits the terminal differentiation of human keratinocytes

    Nature

    (1989)
  • WE Pullman et al.

    Cloning and characterization of a gene that regulates cell adhesion

    Nature

    (1992)
  • AL Frelinger et al.

    Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers

    J Biol Chem

    (1990)
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