Elsevier

Thrombosis Research

Volume 56, Issue 1, 1 October 1989, Pages 67-75
Thrombosis Research

Paper
Thrombus age and tissue plasminogen activator mediated thrombolysis in rats

https://doi.org/10.1016/0049-3848(89)90009-1Get rights and content

Abstract

Thrombolytic efficacy is directly related to thrombus age. We used recombinant tissue plasminogen activator (rt-PA), Streptokinase (SK) and Urokinase (UK) on a seven days old inferior vena cava thrombus model. “In vitro” clot lysis assays with fibrinogen-I125 were also evaluated with the same agents at 1, 3 and 7 days. Fibrinogen, D-D dimer and t-PA were measured. Experiments with 40 controls and 27 rt-PA treated animals showed a significant decrease in thrombus weight (8.5±1.1 mg) vs. (4.2±0.6 mg) (p<0.01). Fibrinogen concentration in rt-PA group decreased significantly (1032±123 mg/dl) vs. (202±32 mg/dl) (p<0.001). “In vitro” rt-PA showed a marked lytic effect in a wide range (100-4 IU/ml). Fibrin selective agents as rt-PA may be more effective than non selective ones in the treatment of fully developed thrombus.

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