Monosomy 3 and isochromosome 8q in a uveal melanoma

https://doi.org/10.1016/0165-4608(90)90090-WGet rights and content

Abstract

Chromosome analysis of a locally invasive uveal melanoma revealed monosomy 3 and i(8q). Sublines with multiple copies of the i(8q) were also present. Loss of heterozygosity for genes on chromosome 3 and duplication of genes on 8q may play an important role in progression of uveal melanoma.

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