Monosomy 3 and isochromosome 8q in a uveal melanoma
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Recent approaches for the treatment of uveal melanoma: Opportunities and challenges
2024, Critical Reviews in Oncology/HematologyRegulation of epigenetic homeostasis in uveal melanoma and retinoblastoma
2022, Progress in Retinal and Eye ResearchTranslation of single-cell transcriptomic analysis of uveal melanomas to clinical oncology
2021, Progress in Retinal and Eye ResearchCitation Excerpt :Several other clinical and histological features are used to complement the conventional AJCC UM staging and patient prognosis (Kaliki et al., 2015; Mäkitie et al., 1999) (Fig. 1). However, a major twist came from cytogenetic studies identifying that the recurrent loss of chromosome 3 and gain of chromosome 8q in tumours (Horsman et al., 1990; Prescher et al., 1992; Sisley et al., 1990) were associated with poor prognosis tumours (Damato et al, 2007, 2009; Jager et al., 2020; Pandiani et al., 2017; Smit et al., 2020; Trolet et al., 2009). Adding chromosome status together with the AJCC resulted in an even better system (Bagger et al., 2015).
Uveal melanoma pathobiology: Metastasis to the liver
2021, Seminars in Cancer BiologyCitation Excerpt :The majority of UMs exhibit a low degree of aneuploidy and chromosomal rearrangements compared with other types of cancers [59–61]. The most frequent chromosomal changes found in UM are the loss of one copy of chromosome 3 (monosomy 3; almost half of UMs) and the amplification of chromosome 8q (40 % of UMs), both associated with a poor prognosis [62–65]. The BAP1 gene (frequently mutated in metastatic UMs) and oncogenes of interest such as MYC, DDEF1 and NBS1 (all overexpressed in UMs with poor prognosis) are located at chromosomes 3p21 and 8q24, respectively [66–69].
PRAME Expression: A Target for Cancer Immunotherapy and a Prognostic Factor in Uveal Melanoma
2023, Investigative Ophthalmology and Visual ScienceMicrophthalmia-Associated Transcription Factor: A Differentiation Marker in Uveal Melanoma
2023, International Journal of Molecular Sciences