Inhibitors of lipoxygenase have antiproliferative effects on P815 murine mastocytoma cells
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5(S)-hydroxyeicosatetraenoic acid stimulates DNA synthesis in human microvascular endothelial cells via activation of Jak/STAT and phosphatidylinositol 3-kinase/Akt signaling, leading to induction of expression of basic fibroblast growth factor 2
2002, Journal of Biological ChemistryCitation Excerpt :Considering these novel observations, it is likely that 5(S)-HETE plays an important role in angiogenesis. A large body of pharmacological data indicates that the LOX metabolites of arachidonic acid are involved in tumorigenesis (14, 15, 17). In this aspect, the present study identifies 5(S)-HETE as one of the LOX products of arachidonic acid that is a potent mitogen for microvessel endothelial cells.
Biology and pathophysiology of leukotrienes
1996, Critical Reviews in Oncology/HematologyRole of hydroperoxyeicosatetraenoic acids in oxidative stress-induced activating protein 1 (Ap-1) activity
1996, Journal of Biological ChemistryInhibition of mammalian hepatic glutathione S-transferases by acetylenic fatty acids
1994, Toxicology LettersDifferential effects of 15-HPETE and 15-HETE on BHK-21 cell proliferation and macromolecular composition
1993, Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
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