Cerebrovascular autoregulation in response to hypertension induced by NG-nitro-l-arginine methyl ester
References (51)
- et al.
Release of nitric oxide from human smooth muscle cells
Biochem. biophys. Res. Commun.
(1991) - et al.
Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation
Neurosci. Lett.
(1993) - et al.
Physiological role of cerebrovascular sympathetic nerves in the autoregulation of cerebral blood flow
Brain Res.
(1976) - et al.
NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices
Eur. J. Pharmac.
(1989) - et al.
Nitric oxide synthesis couples cerebral blood flow and metabolism
Brain Res.
(1992) - et al.
Nitric oxide synthase-containing neural processes on large cerebral arteries and cerebral microvessels
Brain Res.
(1993) - et al.
The effects of the GABAergic agonist muscimol upon the relationship between local cerebral blood flow and glucose utilization
Brain Res.
(1983) - et al.
Acute cocaine alters cerebrovascular autoregulation in the rat neocortex
Brain Res. Bull.
(1993) - et al.
Nitric oxide as a neuronal messenger
Trends pharmac. Sci.
(1991) - et al.
Cerebrovascular NADPH diaphorase-containing nerve fibers in the rat
Neurosci. Lett.
(1993)
Inhibition of nitric oxide synthesis induces a significant reduction in local cerebral blood flow in the rat
Neurosci. Lett.
Histochemical mapping of nitric oxide synthase in the rat brain
Neuroscience
Localization of nitric oxide synthase indicating a neural role for nitric oxide
Nature
Sympathetic control of cerebral blood flow in acute arterial hypertension
Acta physiol. scand.
Relationships between local cerebral blood flow and glucose utilization in the rat
Neurology
Effects of angiotension II on cerebral blood vessels
Acta physiol. scand.
Cerebral blood flow autoregulation at high arterial pressures and different levels of hypercapnia
Eur. Neurol.
Role of endothelium-derived relaxing factor in cerebral circulation: large arteries vs. microcirculation
Am. J. Physiol.
Control of regional blood flow by endothelium-derived nitric oxide
Hypertension
Haemodynamic effects of NG-monomethyl-l-arginine and NG-nitro-l-arginine methyl ester in conscious, unrestrained rats
J. cardiovasc. Pharmac.
Nitric oxide mediates the neurogenic vasodilation of bovine cerebral arteries
J. cerebr. Blood Flow Metab.
Cerebral circulatory effects of fulminating neurogenic hypertension
Does nitric oxide mediate the increase in cerebral blood flow elicited by hypercapnia?
Role of nitric oxide synthase-containing vascular nerves in cerebrovasodilation elicited from cerebellum
Am. J. Physiol.
Effects of NG-nitro-l-arginine andl-arginine on cerebral blood flow in the cat
J. Physiol.
Cited by (37)
Nutrition for the ageing brain: Towards evidence for an optimal diet
2017, Ageing Research ReviewsCitation Excerpt :Future studies should utilize l-arginine analogues such as nitro-l-arginine methyl ester, nitro-l-arginine, and L-N G-mono-methyl-arginine (L-NMMA) to help provide information on the role of NO and blood flow in mediating cognitive activity of polyphenols. Use of L-NMMA in humans has been shown to result in a fall in cerebral blood flow (Shabeeh et al., 2013) without altering basal metabolic activity (Kelly et al., 1994). The use of NOS inhibitors in vivo has the potential to assess the contribution that NO plays in mediating increases in cerebral blood flow and hyperemic responses to cognitive activity in response to flavonoid intervention.
Myogenic and metabolic feedback in cerebral autoregulation: Putative involvement of arachidonic acid-dependent pathways
2016, Medical HypothesesCitation Excerpt :Given that metabolic feedback involves an oxygen sensing mechanism that modulates cerebrovascular myogenic tone, a vasodilating metabolite that antagonises the 20-HETE-dependent pathways on cerebrovascular tone is likely involved. Even though nitric oxide is such a classic functional antagonist of 20-HETE signalling [54], a number of studies stress that it is a mere modulator and not a mediator of cerebral autoregulation [55–64]. In the following section, I propose epoxyeicosatrienoic acids (EETs) as more likely mediators of autoregulatory vasodilation.
Acute tryptophan depletion in rats alters the relationship between cerebral blood flow and glucose metabolism independent of central serotonin
2009, NeuroscienceCitation Excerpt :Further analysis of brain tissue revealed that ATD had no significant effect upon other central AA concentration, with the exception of CIT where a decrease in hippocampal CIT concentration was found only in the TRP− group. A similar decrease in the central concentrations of CIT following ATD has also been observed previously by others (Lieben et al., 2004a), and given that ARG is catalysed into CIT and nitric oxide (NO) (Dawson and Dawson, 1996), it has been proposed that decreases in CIT might parallel decreases in nitric oxide synthesis (NOS) and that such a mechanism might underlie the effects that ATD has upon memory processing (Prast and Philippu, 2001), and could also influence cerebral blood vessels (Kelly et al., 1994). Under normal physiological conditions, the rate of glucose metabolism in the brain provides an index of changes in regional neuronal activity and changes in glucose metabolism are found to be closely coupled to changes in cerebral blood flow (Sokoloff, 1981b; Kuschinsky, 1991).
[22] Nitric oxide in regulation of microvascular tone: Methods of detection
1996, Methods in NeurosciencesNo effect of acute tryptophan depletion on phosphodiesterase inhibition-related improvements of short-term object memory in male Wistar rats
2013, Acta Psychiatrica Scandinavica