Review
Clusterin: Physiologic and pathophysiologic considerations

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Abstract

Clusterin is a heterodimeric glycoprotein produced by a wide array of tissues and found in most biologic fluids. A number of physiologic functions have been proposed for clusterin based on its distribution and in vitro properties. These include complement regulation, lipid transport, sperm maturation, initiation of apoptosis, endocrine secretion, membrane protection, and promotion of cell interactions. A prominent and defining feature of clusterin is its induction in such disease states as glomerulonephritis, polycystic kidney disease, renal tubular injury, neurodegenerative conditions including Alzheimer's disease, atherosclerosis, and myocardial infarction. The expression of clusterin in these states is puzzling, from the specific molecular species and cellular pathways eliciting such expression, to the roles subserved by clusterin once induced. This review will discuss these physiologic and pathophysiologic aspects of clusterin and speculate on its role in disease.

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      Citation Excerpt :

      When we commenced writing this article, we performed a search of Scopus using the term "clusterin” and identified more than 4500 articles. We refer the reader to the numerous excellent review and perspective articles on the biochemistry of CLU, a selection of which are listed here (Jenne and Tschopp 1992; May and Finch, 1992; Rosenberg et al., 1993; Rosenberg and Silkensen 1995; Wilson and Easterbrook-Smith 2000; Jones and Jomary 2002; Trougakos and Gonos 2002; Koltai 2014; Yerbury et al., 2016); (Satapathy and Wilson 2021). In humans, a single CLU gene of nine exons is located on chromosome 8.

    View all citing articles on Scopus
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