Original articleSpectral-Domain Optical Coherence Tomography Imaging in 67 321 Adults: Associations with Macular Thickness in the UK Biobank Study
Section snippets
Study Population
The UKBB study is a large, multisite, community-based cohort study with the overarching aim of improving the prevention, detection, and treatment of a wide range of serious and life-threatening diseases. The study invited people aged 40 to 69 years to take part. All UK residents aged 40 to 69 years who were registered with the National Health Service and living up to 25 miles from 1 of the 22 study assessment centers were invited to participate. The North West Multi-centre Research Ethics
Results
A total of 67 321 participants had OCT imaging as part of the UKBB study. Of these, 32 062 healthy subjects with good-quality imaging were identified. Figure 1 shows a summary of the numbers of eyes and subjects selected and included. Figure 2 provides examples of excluded scans based on use of scan quality indicators. The mean ± SD age of subjects included in the analysis was 55.2±8.2 years, and 17 275 subjects (53.9%) were women. The demographics of the population included and excluded from
Discussion
The UKBB study provides a unique opportunity to explore determinants of macular morphology and thickness in a large cohort of patients aged 40 to 69 years. There were 67 321 subjects who had SD OCT imaging of the macula performed as part of the UKBB study. The results of remotely accessing the UKBB. fds Topcon 3D OCT-1000 files and applying automated segmentation to derive macular thickness measurements identified scans from 32 062 subjects with good visual acuity that were of high image
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Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
P.J.F.: Supported by the Richard Desmond Charitable Trust via Fight for Sight (1956), Special Trustees of Moorfields Eye Hospital (ST 12 09), and Department for Health through an award from the National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust (BRC2_009). The research was supported by the NIHR Biomedical Research Centre based at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology. The views expressed are those of the author(s) and not necessarily those of the NHS, NIHR, or Department of Health. The funding organizations had no role in the design or conduct of this research.
The UKBB was established by the Wellcome Trust Medical Charity, Medical Research Council, Department of Health, Scottish Government, and Northwest Regional Development Agency, and has had funding from the Welsh Assembly Government, British Heart Foundation, and Diabetes UK.
Author Contributions:
Conception and design: Patel, Foster, Keane, Strouthidis, Yang
Data collection: Patel, Grossi, Ko, Reisman, Yang
Analysis and interpretation: Patel, Foster, Grossi, Ko, Lotery, Reisman, Strouthidis, Yang
Obtained funding: Not applicable
Overall responsibility: Patel, Foster, Keane, Ko, Lotery, Peto, Reisman, Strouthidis, Yang
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The UKBB Eyes and Vision Consortium is available online at www.aaojournal.org.