Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment☆
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Patients and methods
This study was conducted according to the tenets of the Declaration of Helsinki and was carried out after receiving approval from the institutional review committee of Kansai Medical University. After an explanation of the purpose of the experiment was presented, informed consent was obtained from all patients.
Undiluted vitreous samples were collected from 34 eyes of 33 individuals undergoing pars plana vitrectomy for the treatment of diabetic retinopathy and other retinal disorders at the
Results
The mean vitreous level of pigment epithelium-derived factor was 1.15 ± 0.23 μg/ml in eyes with diabetic retinopathy, 3.28 ± 0.69 μg/ml in eyes with rhegmatogenous retinal detachment, and 1.71 ± 0.39 μg/m in eyes with an idiopathic macular hole (Figure 1). The mean concentration of pigment epithelium-derived factor in eyes with diabetic retinopathy was significantly lower than the level in eyes with rhegmatogenous retinal detachment (P = .0008), and also lower than that in eyes with an
Discussion
Pigment epithelium-derived factor has been recently shown to inhibit neovascularization in rat corneas, to inhibit the proliferation of capillary endothelial cells, and to inhibit the migration of endothelial cells toward angiogenic inducers, such as platelet-derived factor and vascular endothelial growth factor.9 The vitreous humor has been shown to have antiangiogenic properties,13 and removal of pigment epithelium-derived factor from the vitreous fluid abrogates this antiangiogenic activity.
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This study was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education in Japan.