Original articleSpontaneous resolution of early-onset esotropia: experience of the congenital esotropia observational study22☆,
Section snippets
Methods
The study was conducted by 137 investigators at 104 clinical sites. Investigators were fellowship-trained pediatric ophthalmologists with at least 1 year of clinical practice experience. An institutional review board approved the study for each site and written informed consent was obtained for participation. An independent monitoring committee provided study oversight.
Baseline characteristics
: Between December 1997 and July 2000, 175 patients were enrolled by 137 certified investigators. The age of the patients at the time of the initial visit (baseline) ranged from 4 weeks (29 days) to 19 weeks (139 days) and averaged 14 weeks (97 ± 26 days); 54% of the patients were female and 76% were Caucasian.
The esotropia at baseline was characterized as constant in 98 (56%) of the patients, variable in 43 (25%), and intermittent in 34 (19%). Most of the large-angle deviations (≥ 40 pd) were
Discussion
In this multicenter observational study of 170 patients with early-onset esotropia who were enrolled at 4 to < 20 weeks of age, we found that the esotropia resolved without surgery by the outcome examination (at 28 to 32 weeks of age in most patients) in 46 patients (27%). Resolution was spontaneous in 42 patients and concomitant with spectacle wear in 4 patients. Whether wearing spectacles contributed to the resolution in these patients is unknown since most patients who had hyperopia treated
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2022, Advances in Ophthalmology and OptometryCitation Excerpt :An outcome visit was conducted between 28 and 32 weeks of age. The esotropia resolved in 27% of patients, 8.7% of whom were treated with spectacles [4]. An additional 4% of patients experienced resolution after the end of the study but before the age of 1 year [4].
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2019, Journal Francais d'OphtalmologieCitation Excerpt :However, discrepancies on when to perform surgery are reported throughout the world. For instance, In North America, the typical age at surgery ranges from 11 to 18 months, and in many parts of Western Europe, surgery is delayed until 2 to 4 years of age or even later, given the probability of spontaneous resolution in some cases of esotropia [19,20]. Some limitations have to be accounted, for instance the small sample studied.
Long-term Surgical Outcomes for Large-angle Infantile Esotropia
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Supported by a cooperative agreement from the National Eye Institute, Bethesda, MD: EY11751 and EY12107.
- 1
A complete list of the Investigator group is listed at the end of this article.
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Address reprint requests to PEDIG Data Coordinating Center, Jaeb Center for Health Research, 3010 East 138th Avenue, Suite 9, Tampa, FL 33613; e-mail: [email protected]