Original articleOptical coherence tomography findings following photodynamic therapy of choroidal neovascularization
Section snippets
Methods
All eyes treated with PDT at the New England Eye Center in Boston, Massachusetts, between November 1999 and December 2000 were identified from a manually recorded laser log. Fluorescein angiography and charts of all eyes that had undergone treatment were retrospectively reviewed. Choroidal neovascularization secondary to non-AMD etiologies including inflammatory, idiopathic, pathologic myopia, angioid streaks, and presumed ocular histoplasmosis were excluded. For inclusion in the study, eyes
Stage I: acute inflammatory response
: Immediately following PDT, both OCT and FA demonstrated evidence of an acute inflammatory response. This was confirmed on imaging modalities at 1 hour and up to 1 week following photoactivation of verteporfin. Fluorescein angiography revealed hyperfluorescence of both the CNV and treatment area, with later frames of the angiogram demonstrating increased leakage of fluorescein in the treatment zone. The OCT demonstrated increased accumulation of intraretinal fluid in a circular distribution
Discussion
Optical coherence tomography is a sensitive tool that provides cross-sectional images and reproducible measurements of the macula.11 When scanning eyes with AMD, CNV is imaged in the intraretinal space as a highly reflective red signal. Histologic studies of laser-induced CNV confirm that RPE cells arising from the RPE/choriocapillaris layer envelop CNV, creating the highly reflective band in the retina.12, 13 Retinal fluid collections appear as hyporeflective black spaces either in the
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