Scanning laser polarimetry with variable corneal compensation and optical coherence tomography in normal and glaucomatous eyes☆,☆☆
Section snippets
Design
This was a cross-sectional analysis involving normal and glaucomatous eyes.
Methods
Normal and glaucomatous eyes meeting the eligibility criteria were enrolled in this prospective study. Informed consent was obtained from all subjects by means of a consent form approved by the Institutional Review Board for Human Research of the University of Miami School of Medicine. All patients underwent complete ophthalmic examination, including slit-lamp biomicroscopy, gonioscopy, Goldmann applanation tonometry, dilated stereoscopic examination of the optic disk and fundus, achromatic
Results
Fifty-nine patients (59 eyes; 29 normal, 30 glaucomatous) were enrolled (mean age 56.7 ± 20.3 years, range 20–91). All eyes with glaucoma had associated visual field loss (average mean defect, –8.4 ± 5.8 dB). There were no differences between the groups (Table 1) with regard to sex or race, but glaucoma patients were older and had significantly worse (P < .0001) visual field indices.
Eyes with corneal birefringence values that deviated significantly from the fixed compensator had considerable
Discussion
Conventional SLP is limited by marked interindividual variability of the corneal birefringence measurements in the population.21, 22, 23, 25 Greenfield and associates26 have reported a significant increase in the diagnostic precision of the technology by incorporating eye specific corneal polarization axis measurements calculated by a corneal polarimeter into a statistical logistic regression model. The improvement in the discriminating power was especially marked in the five mean-based
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Cited by (97)
The Use of Optic Disc and Retinal Nerve Fiber Imaging in Detecting Structural Damage Before the Onset of Functional Loss
2017, Advances in Ophthalmology and OptometryCitation Excerpt :This profile is then taken into account to calculate the RNFL retardation after neutralizing eye-specific confounding factors from anterior segment polarization. Use of GDx-VCC demonstrated improved detection of decreased RNFL retardation in glaucomatous eyes compared with GDx-FCC when correlated with visual field function and measurements with OCT [27]. GDx with enhanced corneal compensation (GDx-ECC) was later developed with built-in software changes that accounted for atypical birefringence patterns (ABPs) seen with GDx-VCC.
Retinal nerve fiber thickness is reduced in sleep apnea syndrome
2013, Sleep MedicineCitation Excerpt :One of the recent generation of polarimeters (GDx-VCC), which provides a customized compensation of anterior segment birefringence, has been used for earlier diagnosis of glaucoma [3]. This device has been used to evaluate differences in retardation between normal and glaucomatous eyes and between normal subjects and patients with ocular hypertension (OHTN) [23,24]. GDx VCC has been shown to be effective in differentiating eyes with glaucoma from normals with a sensitivity and specificity >90% [21].
Polarization sensitive optical coherence tomography in the human eye
2011, Progress in Retinal and Eye ResearchRelationship between standard automated perimetry and retinal nerve fiber layer parameters measured with laser polarimetry
2010, Archivos de la Sociedad Espanola de OftalmologiaAltered F-actin distribution in retinal nerve fiber layer of a rat model of glaucoma
2009, Experimental Eye Research
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This study was supported in part by the New York Community Trust, New York, New York; a grant from Mr Barney Donnelley, Palm Beach, Florida; and National Institutes of Health Grant R01-EY08684, Bethesda, Maryland. Doctor Greenfield is a member of the Scientific Advisory Board, Laser Diagnostic Technology, San Diego, California.
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InternetAdvance publication at ajo.com Jan 6, 2003.