What is the risk of developing pigmentary glaucoma from pigment dispersion syndrome?☆
Section snippets
Design
This was a retrospective study of all patients living in Olmsted County, Minnesota, diagnosed with either pigment dispersion syndrome or pigmentary glaucoma between 1976 and 1999. Patients were identified through the Rochester Epidemiology Project, a medical records linkage system established to study the occurrence and natural history of disease among residents of Rochester and the balance of Olmsted County, Minnesota.8, 9 It was a “community-based” study, to distinguish it from studies of
Methods
The study was done in two parts: assessment of the probability of converting from pigment dispersion syndrome to pigmentary glaucoma, and estimation of the incidence rates of these conditions over the 23-year period of the study.
Results
A total of 136 patients were included in the study; 113 patients were diagnosed with pigment dispersion syndrome over the 24-year interval from 1976 to 1999. An additional 23 patients were found to have pigmentary glaucoma on initial examination during this same interval. All patients were white. For comparison, the population of Olmsted County in 1990 was 95% white, 3% Asian, and 0.72% black.
Discussion
The risk of developing pigmentary glaucoma from pigment dispersion syndrome is low but not insignificant: 10% at 5 years, increasing to 15% by 15 years. The most predictive factor for conversion was IOP greater than 21 mm Hg at initial diagnosis of pigment dispersion. Each 1-mm Hg increase in IOP in patients with pigment dispersion syndrome increased the risk of conversion to pigmentary glaucoma 1.4 times (95% CI, 1.2 to 1.6). Based on this, patients with pigment dispersion syndrome with IOP
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Cited by (130)
Unilateral pigmentary glaucoma in a patient with Horner's syndrome: Case report
2024, Journal Francais d'OphtalmologieGlaucoma: now and beyond
2023, The LancetPigment dispersion syndrome and its implications for glaucoma
2021, Survey of OphthalmologyCitation Excerpt :The diagnosis of PDS is primarily clinical, and most patients respond well to medical or laser therapy, although surgery is necessary in some cases.30 The prognosis of PDS depends on the potential development of POHT or PG. The dispersion of iris pigment is classified as PDS with normal intraocular pressure (IOP), PDS with POHT, or PG.78 Friedrich E. Krukenberg first identified a vertical pigment deposition on the corneal endothelium in 1899.
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InternetAdvance publication at ajo.com Feb 26, 2003.