Uveal metastasis from breast cancer in 264 patients☆
Section snippets
Methods
The medical records of all patients with the diagnosis of uveal metastatic tumor evaluated on the Ocular Oncology Service at Wills Eye Hospital, Philadelphia, Pennslyvania, between January 1974 and September 2001 were identified. Those patients in whom the primary cancer was proven to be of breast origin were selected for further analysis and included in this study. The criteria for the clinical diagnosis of metastasis have been published.1, 14 The diagnosis was made with clinical findings and
Results
The mean age at the initial diagnosis of primary breast cancer was 56 years (median, 57 years; range, 23–84 years). There were 261 (99%) females and 3 (1%) males. Of 264 patients, 242 (92%) were Caucasian, 19 (7%) African American, 2 (<1%) Asian, and 1 (<1%) Hispanic. The affected breast was right in 132 patients (50%), left in 119 patients (45%), and both in 13 patients (5%). The initial treatment of breast cancer was radical or modified mastectomy in 218 patients (83%), systemic chemotherapy
Discussion
Breast cancer is the most common cancer in women and second leading cause of cancer death among women in developed countries.8, 15 The age-adjusted incidence of breast cancer has increased by 35% during the 1980s, rising from a rate of 85/100,000 women in 1980 to a rate of 121/100,000 in 1998.16 In the United States, a woman’s lifetime risk of developing breast cancer has also increased dramatically from one of 14 women in the 1970s to one of every eight women in the 2001.17 According to
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InternetAdvance publication at ajo.com Feb 6, 2003.