Optical Coherence Tomography of Central Serous Chorioretinopathy

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Purpose

To assess the potential of a new imaging technique, optical coherence tomography, for the diagnosis and monitoring of central serous chorioretinopathy. Optical coherence tomography is a novel noninvasive, noncontact imaging modality that produces high longitudinal resolution, cross-sectional tomographs of ocular tissue.

Methods

Optical coherence tomography is analogous to ultrasound, except that it uses light rather than sound to obtain higher image resolution in the retina. Cross-sectional tomographs of optical reflectivity within the retina are produced with longitudinal resolution of 10 μm. Optical coherence tomography was used to examine 16 patients at a referral eye center whose initial examination disclosed the clinical diagnosis of central serous chorioretinopathy. The optical coherence tomography results were correlated with slit-lamp biomicroscopy, fundus photography, and fluorescein angiography.

Results

The cross-sectional view produced by optical coherence tomography was effective in objectively quantifying the amount of serous retinal detachment in the disease. Optical coherence tomography disclosed detachments that were undetected by slit-lamp biomicroscopy. Longitudinal measurements with optical coherence tomography were successfully able to track the resolution of subretinal fluid accumulation.

Conclusion

Optical coherence tomography is potentially useful as a new, noninvasive diagnostic technique for quantitative examination of patients with central serous chorioretinopathy and objectively monitoring the clinical course of the serous retinal detachment in this disease.

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This study was performed at the New England Eye Center, Tufts University School of Medicine, Boston, Massachusetts. This study was supported in part by grant RO-1-GM35459-08 from the National Institutes of Health, Bethesda, Maryland (Dr. Fujimoto); Medical Free Electron Laser grant N00014-91-C-0084, Washington, D.C. (Dr. Puliafito); and unrestricted departmental grants from Research to Prevent Blindness, Inc., New York, New York, and the Massachusetts Lions Eye Research Fund, Inc., Boston, Massachusetts.

Reprint requests to Carmen A. Puliafito, M.D., New England Eye Center, Tufts University School of Medicine, 750 Washington St., Box 450, Boston, MA 02111; fax: (617) 636-4866.

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